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Plant cysteine oxidases control the oxygen-dependent branch of the N-end-rule pathway

Author

Listed:
  • Daan A. Weits

    (Institute of Life Sciences, Scuola Superiore Sant’Anna
    Max Planck Institute of Molecular Plant Physiology)

  • Beatrice Giuntoli

    (Institute of Life Sciences, Scuola Superiore Sant’Anna)

  • Monika Kosmacz

    (Max Planck Institute of Molecular Plant Physiology)

  • Sandro Parlanti

    (Institute of Life Sciences, Scuola Superiore Sant’Anna)

  • Hans-Michael Hubberten

    (Max Planck Institute of Molecular Plant Physiology)

  • Heike Riegler

    (Max Planck Institute of Molecular Plant Physiology)

  • Rainer Hoefgen

    (Max Planck Institute of Molecular Plant Physiology)

  • Pierdomenico Perata

    (Institute of Life Sciences, Scuola Superiore Sant’Anna)

  • Joost T. van Dongen

    (Max Planck Institute of Molecular Plant Physiology
    Institute of Biology, RWTH Aachen University)

  • Francesco Licausi

    (Institute of Life Sciences, Scuola Superiore Sant’Anna)

Abstract

In plant and animal cells, amino-terminal cysteine oxidation controls selective proteolysis via an oxygen-dependent branch of the N-end rule pathway. It remains unknown how the N-terminal cysteine is specifically oxidized. Here we identify plant cysteine oxidase (PCO) enzymes that oxidize the penultimate cysteine of ERF-VII transcription factors by using oxygen as a co-substrate, thereby controlling the lifetime of these proteins. Consequently, ERF-VII proteins are stabilized under hypoxia and activate the molecular response to low oxygen while the expression of anaerobic genes is repressed in air. Members of the PCO family are themselves targets of ERF-VII transcription factors, generating a feedback loop that adapts the stress response according to the extent of the hypoxic condition. Our results reveal that PCOs act as sensor proteins for oxygen in plants and provide an example of how proactive regulation of the N-end rule pathway balances stress response to optimal growth and development in plants.

Suggested Citation

  • Daan A. Weits & Beatrice Giuntoli & Monika Kosmacz & Sandro Parlanti & Hans-Michael Hubberten & Heike Riegler & Rainer Hoefgen & Pierdomenico Perata & Joost T. van Dongen & Francesco Licausi, 2014. "Plant cysteine oxidases control the oxygen-dependent branch of the N-end-rule pathway," Nature Communications, Nature, vol. 5(1), pages 1-10, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4425
    DOI: 10.1038/ncomms4425
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    Cited by:

    1. Agata Zubrycka & Charlene Dambire & Laura Dalle Carbonare & Gunjan Sharma & Tinne Boeckx & Kamal Swarup & Craig J. Sturrock & Brian S. Atkinson & Ranjan Swarup & Françoise Corbineau & Neil J. Oldham &, 2023. "ERFVII action and modulation through oxygen-sensing in Arabidopsis thaliana," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Karen C. Heathcote & Thomas P. Keeley & Matti Myllykoski & Malin Lundekvam & Nina McTiernan & Salma Akter & Norma Masson & Peter J. Ratcliffe & Thomas Arnesen & Emily Flashman, 2024. "N-terminal cysteine acetylation and oxidation patterns may define protein stability," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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