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An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration

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  • Roberta Azzarelli

    (MRC National Institute for Medical Research, Mill Hill
    Present address: Hutchison/MRC Research Centre, University of Cambridge, Box 197, Biomedical Campus, Cambridge CB2 0XZ, UK)

  • Emilie Pacary

    (MRC National Institute for Medical Research, Mill Hill
    Present address: INSERM, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862, Bordeaux F-33000, France or University Bordeaux, Neurocentre Magendie, Physiopathologie de la plasticité neuronale, U862, Bordeaux F-33000, France)

  • Ritu Garg

    (King's College London)

  • Patricia Garcez

    (MRC National Institute for Medical Research, Mill Hill)

  • Debbie van den Berg

    (MRC National Institute for Medical Research, Mill Hill)

  • Philippe Riou

    (King's College London
    Present address: Protein Phosphorylation Laboratory, Cancer Research UK, London Research Institute, Lincoln's Inn Fields Laboratories, London WC2A 3LY, UK)

  • Anne J. Ridley

    (King's College London)

  • Roland H. Friedel

    (Icahn School of Medicine at Mount Sinai)

  • Maddy Parsons

    (King's College London)

  • François Guillemot

    (MRC National Institute for Medical Research, Mill Hill)

Abstract

A transcriptional programme initiated by the proneural factors Neurog2 and Ascl1 controls successive steps of neurogenesis in the embryonic cerebral cortex. Previous work has shown that proneural factors also confer a migratory behaviour to cortical neurons by inducing the expression of the small GTP-binding proteins such as Rnd2 and Rnd3. However, the directionality of radial migration suggests that migrating neurons also respond to extracellular signal-regulated pathways. Here we show that the Plexin B2 receptor interacts physically and functionally with Rnd3 and stimulates RhoA activity in migrating cortical neurons. Plexin B2 competes with p190RhoGAP for binding to Rnd3, thus blocking the Rnd3-mediated inhibition of RhoA and also recruits RhoGEFs to directly stimulate RhoA activity. Thus, an interaction between the cell-extrinsic Plexin signalling pathway and the cell-intrinsic Ascl1-Rnd3 pathway determines the level of RhoA activity appropriate for cortical neuron migration.

Suggested Citation

  • Roberta Azzarelli & Emilie Pacary & Ritu Garg & Patricia Garcez & Debbie van den Berg & Philippe Riou & Anne J. Ridley & Roland H. Friedel & Maddy Parsons & François Guillemot, 2014. "An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration," Nature Communications, Nature, vol. 5(1), pages 1-12, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4405
    DOI: 10.1038/ncomms4405
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    Cited by:

    1. Thomas Wylie & Ritu Garg & Anne J Ridley & Maria R Conte, 2017. "Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-13, October.

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