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MafB promotes atherosclerosis by inhibiting foam-cell apoptosis

Author

Listed:
  • Michito Hamada

    (University of Tsukuba, 1-1-1, Tennodai
    International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1, Tennodai
    Laboratory Animal Resource Center (LARC), Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai)

  • Megumi Nakamura

    (University of Tsukuba, 1-1-1, Tennodai)

  • Mai Thi Nhu Tran

    (University of Tsukuba, 1-1-1, Tennodai
    International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1, Tennodai)

  • Takashi Moriguchi

    (Tohoku University Graduate School of Medicine)

  • Cynthia Hong

    (Howard Hughes Medical Institute, University of California)

  • Takayuki Ohsumi

    (University of Tsukuba, 1-1-1, Tennodai)

  • Tra Thi Huong Dinh

    (Laboratory Animal Resource Center (LARC), Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai
    University of Tsukuba, 1-1-1, Tennodai)

  • Manabu Kusakabe

    (University of Tsukuba, 1-1-1, Tennodai)

  • Motochika Hattori

    (University of Tsukuba, 1-1-1, Tennodai)

  • Tokio Katsumata

    (University of Tsukuba, 1-1-1, Tennodai)

  • Satoko Arai

    (Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku)

  • Katsuhiko Nakashima

    (Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku)

  • Takashi Kudo

    (University of Tsukuba, 1-1-1, Tennodai
    International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1, Tennodai)

  • Etsushi Kuroda

    (Laboratory of Vaccine Science, WPI Immunology Frontier Research Center (IFReC), Osaka University, 3-1 Yamada-oka)

  • Chien-Hui Wu

    (National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7 Jhong-Shan South Road)

  • Pei-Han Kao

    (Chang Gung Memorial Hospital, No. 199, Tung-Hwa North Road)

  • Masaharu Sakai

    (Faculty of Health Sciences, Hokkaido University, N12, W5, Kita-ku)

  • Hitoshi Shimano

    (International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1, Tennodai
    University of Tsukuba, 1-1-1, Tennodai)

  • Toru Miyazaki

    (Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku)

  • Peter Tontonoz

    (Tohoku University Graduate School of Medicine)

  • Satoru Takahashi

    (University of Tsukuba, 1-1-1, Tennodai
    International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1, Tennodai
    Laboratory Animal Resource Center (LARC), Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai
    Life Science Center, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1, Tennodai)

Abstract

MafB is a transcription factor that induces myelomonocytic differentiation. However, the precise role of MafB in the pathogenic function of macrophages has never been clarified. Here we demonstrate that MafB promotes hyperlipidemic atherosclerosis by suppressing foam-cell apoptosis. Our data show that MafB is predominantly expressed in foam cells found within atherosclerotic lesions, where MafB mediates the oxidized LDL-activated LXR/RXR-induced expression of apoptosis inhibitor of macrophages (AIM). In the absence of MafB, activated LXR/RXR fails to induce the expression of AIM, a protein that is normally responsible for protecting macrophages from apoptosis; thus, Mafb-deficient macrophages are prone to apoptosis. Haematopoietic reconstitution with Mafb-deficient fetal liver cells in recipient LDL receptor-deficient hyperlipidemic mice revealed accelerated foam-cell apoptosis, which subsequently led to the attenuation of the early atherogenic lesion. These findings represent the first evidence that the macrophage-affiliated MafB transcription factor participates in the acceleration of atherogenesis.

Suggested Citation

  • Michito Hamada & Megumi Nakamura & Mai Thi Nhu Tran & Takashi Moriguchi & Cynthia Hong & Takayuki Ohsumi & Tra Thi Huong Dinh & Manabu Kusakabe & Motochika Hattori & Tokio Katsumata & Satoko Arai & Ka, 2014. "MafB promotes atherosclerosis by inhibiting foam-cell apoptosis," Nature Communications, Nature, vol. 5(1), pages 1-14, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4147
    DOI: 10.1038/ncomms4147
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    Cited by:

    1. Niranjana Natarajan & Jonathan Florentin & Ebin Johny & Hanxi Xiao & Scott Patrick O’Neil & Liqun Lei & Jixing Shen & Lee Ohayon & Aaron R. Johnson & Krithika Rao & Xiaoyun Li & Yanwu Zhao & Yingze Zh, 2024. "Aberrant mitochondrial DNA synthesis in macrophages exacerbates inflammation and atherosclerosis," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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