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The central role of EED in the orchestration of polycomb group complexes

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  • Qi Cao

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School
    Center for Inflammation and Epigenetics, Houston Methodist Research Institute
    Cancer Center, Houston Methodist Research Institute)

  • Xiaoju Wang

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Meng Zhao

    (Emory University)

  • Rendong Yang

    (Emory University)

  • Rohit Malik

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Yuanyuan Qiao

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Anton Poliakov

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Anastasia K. Yocum

    (Michigan Center for Translational Pathology, University of Michigan Medical School)

  • Yong Li

    (Michigan Center for Translational Pathology, University of Michigan Medical School)

  • Wei Chen

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Xuhong Cao

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    Howard Hughes Medical Institute, University of Michigan Medical School)

  • Xia Jiang

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Arun Dahiya

    (Michigan Center for Translational Pathology, University of Michigan Medical School)

  • Clair Harris

    (University of Michigan Medical School)

  • Felix Y. Feng

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School
    Comprehensive Cancer Center, University of Michigan Medical School)

  • Sundeep Kalantry

    (University of Michigan Medical School)

  • Zhaohui S. Qin

    (Emory University
    Center for Comprehensive Informatics, Emory University)

  • Saravana M. Dhanasekaran

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School)

  • Arul M. Chinnaiyan

    (Michigan Center for Translational Pathology, University of Michigan Medical School
    University of Michigan Medical School
    Howard Hughes Medical Institute, University of Michigan Medical School
    Comprehensive Cancer Center, University of Michigan Medical School)

Abstract

Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. EED functions to recruit PRC1 to H3K27me3 loci and enhances PRC1-mediated H2A ubiquitin E3 ligase activity. Taken together, we suggest an integral role for EED as an epigenetic exchange factor coordinating the activities of PRC1 and 2.

Suggested Citation

  • Qi Cao & Xiaoju Wang & Meng Zhao & Rendong Yang & Rohit Malik & Yuanyuan Qiao & Anton Poliakov & Anastasia K. Yocum & Yong Li & Wei Chen & Xuhong Cao & Xia Jiang & Arun Dahiya & Clair Harris & Felix Y, 2014. "The central role of EED in the orchestration of polycomb group complexes," Nature Communications, Nature, vol. 5(1), pages 1-13, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4127
    DOI: 10.1038/ncomms4127
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    Cited by:

    1. Tsukasa Nabekura & Elfira Amalia Deborah & Saeko Tahara & Yuya Arai & Paul E. Love & Koichiro Kako & Akiyoshi Fukamizu & Masafumi Muratani & Akira Shibuya, 2023. "Themis2 regulates natural killer cell memory function and formation," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Julian Cheron & Leonardo Beccari & Perrine Hagué & Romain Icick & Chloé Despontin & Teresa Carusone & Matthieu Defrance & Sagar Bhogaraju & Elena Martin-Garcia & Roberto Capellan & Rafael Maldonado & , 2023. "USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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