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Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne

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  • Li He

    (First Affiliated Hospital of Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan province)

  • Wen-Juan Wu

    (First Affiliated Hospital of Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan province)

  • Jian-Kang Yang

    (Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University
    State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences)

  • Hui Cheng

    (Anhui Medical University
    Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education)

  • Xian-Bo Zuo

    (Anhui Medical University
    Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education)

  • Wei Lai

    (the Third Affiliated Hospital of Sun Yat-sen University)

  • Tian-Wen Gao

    (Xijing Hospital, Fourth Military Medical University)

  • Cui-Lin Ma

    (Xijing Hospital, Fourth Military Medical University)

  • Na Luo

    (Southwest Hospital, Third Military Medical University)

  • Jian-Qing Huang

    (Fuzhou Dermatosis Prevention Hospital)

  • Feng-Yan Lu

    (Kunming Medical University Affiliated Hospital Qujing (Qujing First People’s Hospital))

  • Ye-Qiang Liu

    (Shanghai Dermatology Hospital)

  • Yi-Jin Huang

    (the First Affiliated Hospital of Xiamen University & the First Hospital of Xiamen)

  • Qian-Jin Lu

    (Second Xiangya Hospital, Central South University)

  • Huai-Liang Zhang

    (Institute of Dermatology, Peking Union Medical College and Chinese Academy of Medical Sciences)

  • Lin Wang

    (West China Hospital of Sichuan University)

  • Wei-Zhen Wang

    (Wuhan No.1 Hospital)

  • Mei-Mei Wang

    (First Affiliated Hospital of Baotou Medical College)

  • Sheng-Xiang Xiao

    (Second Affiliated Hospital of Xi’an Jiaotong University)

  • Qing Sun

    (Qilu Hospital of Shandong University)

  • Chun-Yang Li

    (Qilu Hospital of Shandong University)

  • Yan-Ping Bai

    (China-Japan Friendship hospital)

  • Hui Li

    (the First Affiliated Hospital of Chongqing Medical University)

  • Zhan-Chao Zhou

    (Winona medical cosmetic center)

  • Fu-Sheng Zhou

    (Anhui Medical University
    Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education)

  • Gang Chen

    (Anhui Medical University
    Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education)

  • Bo Liang

    (Anhui Medical University
    Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education)

  • Jue Qi

    (First Affiliated Hospital of Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan province)

  • Xiao-Yan Yang

    (First Affiliated Hospital of Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan province)

  • Ting Yang

    (First Affiliated Hospital of Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan province)

  • Xing Zheng

    (State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences)

  • Liang-Dan Sun

    (Anhui Medical University
    Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education)

  • Xue-Jun Zhang

    (Anhui Medical University
    Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education)

  • Ya-Ping Zhang

    (State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences)

Abstract

Severe acne is a chronic inflammatory skin disorder characterized by widespread inflammatory lesions including nodules, cysts and potential scarring. Here we perform the first genome-wide association study of severe acne in a Chinese Han population comprising 1,056 cases and 1,056 controls using the Illumina HumanOmniZhongHua-8 BeadChip. In an independent cohort of 1,860 cases and 3,660 controls of Chinese Han, we replicate 101 SNPs of which 3 showed consistent association. We identify two new susceptibility loci at 11p11.2 (DDB2, rs747650, Pcombined=4.41 × 10−9 and rs1060573, Pcombined=1.28 × 10−8) and 1q24.2 (SELL, rs7531806, Pcombined=1.20 × 10−8) that are involved in androgen metabolism, inflammation processes and scar formation in severe acne. These results point to new genetic susceptibility factors and suggest several new biological pathways related to severe acne.

Suggested Citation

  • Li He & Wen-Juan Wu & Jian-Kang Yang & Hui Cheng & Xian-Bo Zuo & Wei Lai & Tian-Wen Gao & Cui-Lin Ma & Na Luo & Jian-Qing Huang & Feng-Yan Lu & Ye-Qiang Liu & Yi-Jin Huang & Qian-Jin Lu & Huai-Liang Z, 2014. "Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne," Nature Communications, Nature, vol. 5(1), pages 1-7, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms3870
    DOI: 10.1038/ncomms3870
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    Cited by:

    1. Brittany L. Mitchell & Jake R. Saklatvala & Nick Dand & Fiona A. Hagenbeek & Xin Li & Josine L. Min & Laurent Thomas & Meike Bartels & Jouke Hottenga & Michelle K. Lupton & Dorret I. Boomsma & Xianjun, 2022. "Genome-wide association meta-analysis identifies 29 new acne susceptibility loci," Nature Communications, Nature, vol. 13(1), pages 1-9, December.

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