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MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice

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Listed:
  • Takahiro Horie

    (Graduate School of Medicine, Kyoto University
    Institute for Advancement of Clinical and Translational Science, Graduate School of Medicine, Kyoto University)

  • Tomohiro Nishino

    (Graduate School of Medicine, Kyoto University)

  • Osamu Baba

    (Graduate School of Medicine, Kyoto University)

  • Yasuhide Kuwabara

    (Graduate School of Medicine, Kyoto University)

  • Tetsushi Nakao

    (Graduate School of Medicine, Kyoto University)

  • Masataka Nishiga

    (Graduate School of Medicine, Kyoto University)

  • Shunsuke Usami

    (Graduate School of Medicine, Kyoto University)

  • Masayasu Izuhara

    (Graduate School of Medicine, Kyoto University)

  • Naoya Sowa

    (Graduate School of Medicine, Kyoto University)

  • Naoya Yahagi

    (Graduate School of Comprehensive Human Sciences, Nutrigenomics Research Group, Faculty of Medicine, and International Institute for Integrative Sleep Medicine (IIIS), World Premir International Research Center Initiative (WPI), University of Tsukuba)

  • Hitoshi Shimano

    (Graduate School of Comprehensive Human Sciences, Nutrigenomics Research Group, Faculty of Medicine, and International Institute for Integrative Sleep Medicine (IIIS), World Premir International Research Center Initiative (WPI), University of Tsukuba)

  • Shigenobu Matsumura

    (Laboratory of Nutrition Chemistry, Graduate School of Agriculture, Kyoto University)

  • Kazuo Inoue

    (Laboratory of Nutrition Chemistry, Graduate School of Agriculture, Kyoto University)

  • Hiroyuki Marusawa

    (Graduate School of Medicine, Kyoto University)

  • Tomoyuki Nakamura

    (Kansai Medical University)

  • Koji Hasegawa

    (National Hospital Organization, Kyoto Medical Center)

  • Noriaki Kume

    (Faculty of Pharmaceutical Sciences, Kobe Gakuin University)

  • Masayuki Yokode

    (Institute for Advancement of Clinical and Translational Science, Graduate School of Medicine, Kyoto University)

  • Toru Kita

    (Kobe City Medical Center General Hospital)

  • Takeshi Kimura

    (Graduate School of Medicine, Kyoto University)

  • Koh Ono

    (Graduate School of Medicine, Kyoto University)

Abstract

MicroRNAs (miRs) are small non-protein-coding RNAs that bind to specific mRNAs and inhibit translation or promote mRNA degradation. Recent reports have indicated that miR-33, which is located within the intron of sterol regulatory element-binding protein (SREBP) 2, controls cholesterol homoeostasis and may be a potential therapeutic target for the treatment of atherosclerosis. Here we show that deletion of miR-33 results in marked worsening of high-fat diet-induced obesity and liver steatosis. Using miR-33−/−Srebf1+/− mice, we demonstrate that SREBP-1 is a target of miR-33 and that the mechanisms leading to obesity and liver steatosis in miR-33−/− mice involve enhanced expression of SREBP-1. These results elucidate a novel interaction between SREBP-1 and SREBP-2 mediated by miR-33 in vivo.

Suggested Citation

  • Takahiro Horie & Tomohiro Nishino & Osamu Baba & Yasuhide Kuwabara & Tetsushi Nakao & Masataka Nishiga & Shunsuke Usami & Masayasu Izuhara & Naoya Sowa & Naoya Yahagi & Hitoshi Shimano & Shigenobu Mat, 2013. "MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice," Nature Communications, Nature, vol. 4(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3883
    DOI: 10.1038/ncomms3883
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    Cited by:

    1. Nathan L. Price & Pablo Fernández-Tussy & Luis Varela & Magdalena P. Cardelo & Marya Shanabrough & Binod Aryal & Rafael Cabo & Yajaira Suárez & Tamas L. Horvath & Carlos Fernández-Hernando, 2024. "microRNA-33 controls hunger signaling in hypothalamic AgRP neurons," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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