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The neuropeptide NLP-22 regulates a sleep-like state in Caenorhabditis elegans

Author

Listed:
  • M.D. Nelson

    (Perelman School of Medicine, University of Pennsylvania)

  • N.F. Trojanowski

    (Perelman School of Medicine, University of Pennsylvania
    University of Pennsylvania)

  • J.B. George-Raizen

    (Perelman School of Medicine, University of Pennsylvania)

  • C.J. Smith

    (Perelman School of Medicine, University of Pennsylvania)

  • C.-C. Yu

    (University of Pennsylvania)

  • C. Fang-Yen

    (University of Pennsylvania
    Korea University, Anam-dong)

  • D.M. Raizen

    (Perelman School of Medicine, University of Pennsylvania)

Abstract

Neuropeptides have central roles in the regulation of homoeostatic behaviours such as sleep and feeding. Caenorhabditis elegans displays sleep-like quiescence of locomotion and feeding during a larval transition stage called lethargus and feeds during active larval and adult stages. Here we show that the neuropeptide NLP-22 is a regulator of Caenorhabditis elegans sleep-like quiescence observed during lethargus. nlp-22 shows cyclical mRNA expression in synchrony with lethargus; it is regulated by LIN-42, an orthologue of the core circadian protein PERIOD; and it is expressed solely in the two RIA interneurons. nlp-22 and the RIA interneurons are required for normal lethargus quiescence, and forced expression of nlp-22 during active stages causes anachronistic locomotion and feeding quiescence. Optogenetic stimulation of the RIA interneurons has a movement-promoting effect, demonstrating functional complexity in a single-neuron type. Our work defines a quiescence-regulating role for NLP-22 and expands our knowledge of the neural circuitry controlling Caenorhabditis elegans behavioural quiescence.

Suggested Citation

  • M.D. Nelson & N.F. Trojanowski & J.B. George-Raizen & C.J. Smith & C.-C. Yu & C. Fang-Yen & D.M. Raizen, 2013. "The neuropeptide NLP-22 regulates a sleep-like state in Caenorhabditis elegans," Nature Communications, Nature, vol. 4(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3846
    DOI: 10.1038/ncomms3846
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    Cited by:

    1. Deepak Sharma & Matthias Renz & Philipp Hövel, 2025. "Discovering motifs to fingerprint multi-layer networks: a case study on the connectome of C. Elegans," The European Physical Journal B: Condensed Matter and Complex Systems, Springer;EDP Sciences, vol. 98(1), pages 1-15, January.

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