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A cholinergic trigger drives learning-induced plasticity at hippocampal synapses

Author

Listed:
  • Dai Mitsushima

    (Yokohama City University Graduate School of Medicine
    Kanagawa Dental University
    Yamaguchi University Graduate School of Medicine)

  • Akane Sano

    (Yokohama City University Graduate School of Medicine)

  • Takuya Takahashi

    (Yokohama City University Graduate School of Medicine
    Albert Einstein College of Medicine)

Abstract

Learning induces plastic changes in synapses. However, the regulatory molecules that orchestrate learning-induced synaptic changes are largely unknown. Although it is well established that cholinergic inputs from the medial septum modulate learning and memory, evidence for the cholinergic regulation of learning-induced synaptic plasticity is lacking. Here we find that the activation of muscarinic acetylcholine (ACh) receptors (mAChRs) mediates the contextual fear learning-driven strengthening of hippocampal excitatory pyramidal synapses through the synaptic incorporation of AMPA-type glutamate receptors (AMPARs). Contextual fear learning also enhances the strength of inhibitory synapses on hippocampal pyramidal CA1 neurons, in a manner mediated by the activation of, not mAChRs, but, nicotinic AChRs (nAChRs). We observe a significant correlation between the learning-induced increases in excitatory and inhibitory synaptic strength at individual pyramidal neurons. Understanding the mechanisms underlying cholinergic regulation of learning-induced hippocampal synaptic plasticity may help the development of new therapies for cognitive disorders.

Suggested Citation

  • Dai Mitsushima & Akane Sano & Takuya Takahashi, 2013. "A cholinergic trigger drives learning-induced plasticity at hippocampal synapses," Nature Communications, Nature, vol. 4(1), pages 1-10, December.
  • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3760
    DOI: 10.1038/ncomms3760
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    1. Panna Hegedüs & Bálint Király & Dániel Schlingloff & Victoria Lyakhova & Anna Velencei & Írisz Szabó & Márton I. Mayer & Zsofia Zelenak & Gábor Nyiri & Balázs Hangya, 2024. "Parvalbumin-expressing basal forebrain neurons mediate learning from negative experience," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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