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Brief hearing loss disrupts binaural integration during two early critical periods of auditory cortex development

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  • Daniel B. Polley

    (Harvard Medical School
    Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary
    Center for Computational Neuroscience and Neural Technology, Boston University)

  • John H. Thompson

    (Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary)

  • Wei Guo

    (Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary
    Center for Computational Neuroscience and Neural Technology, Boston University)

Abstract

Early binaural experience can recalibrate central auditory circuits that support spatial hearing. However, it is not known how binaural integration matures shortly after hearing onset or whether various developmental stages are differentially impacted by disruptions of normal binaural experience. Here we induce a brief, reversible unilateral conductive hearing loss (CHL) at several experimentally determined milestones in mouse primary auditory cortex (A1) development and characterize its effects ~1 week after normal hearing is restored. We find that CHL shapes A1 binaural selectivity during two early critical periods. CHL before P16 disrupts the normal coregistration of interaural frequency tuning, whereas CHL on P16, but not before or after, disrupts interaural level difference sensitivity contained in long-latency spikes. These data highlight an evolving plasticity in the developing auditory cortex that may relate to the aetiology of amblyaudia, a binaural hearing impairment associated with bouts of otitis media during human infancy.

Suggested Citation

  • Daniel B. Polley & John H. Thompson & Wei Guo, 2013. "Brief hearing loss disrupts binaural integration during two early critical periods of auditory cortex development," Nature Communications, Nature, vol. 4(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3547
    DOI: 10.1038/ncomms3547
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    Cited by:

    1. Camille Mazo & Margarida Baeta & Leopoldo Petreanu, 2024. "Auditory cortex conveys non-topographic sound localization signals to visual cortex," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Kelsey L. Anbuhl & Justin D. Yao & Robert A. Hotz & Todd M. Mowery & Dan H. Sanes, 2022. "Auditory processing remains sensitive to environmental experience during adolescence in a rodent model," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Manoj Kumar & Gregory Handy & Stylianos Kouvaros & Yanjun Zhao & Lovisa Ljungqvist Brinson & Eric Wei & Brandon Bizup & Brent Doiron & Thanos Tzounopoulos, 2023. "Cell-type-specific plasticity of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

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