IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v4y2013i1d10.1038_ncomms3496.html
   My bibliography  Save this article

Auxin-Binding Protein 1 is a negative regulator of the SCFTIR1/AFB pathway

Author

Listed:
  • Alexandre Tromas

    (Institut des Sciences du Végétal (ISV), UPR2355 Centre National de la Recherche Scientifique, Saclay Plant Sciences
    Present address: Southern Crop Protection and Food Research Centre, Agriculture and Agri-food Canada, 1391 Sandford Street, London, Ontario, Canada N5V 4T3)

  • Sébastien Paque

    (Institut des Sciences du Végétal (ISV), UPR2355 Centre National de la Recherche Scientifique, Saclay Plant Sciences)

  • Vérène Stierlé

    (Institut des Sciences du Végétal (ISV), UPR2355 Centre National de la Recherche Scientifique, Saclay Plant Sciences
    Present address: Université de Reims Champagne Ardenne, Laboratoire SiRMa, FRE3481, Moulin de la Housse, BP 1039 - 51687 Reims Cedex 2, France)

  • Anne-Laure Quettier

    (Institut des Sciences du Végétal (ISV), UPR2355 Centre National de la Recherche Scientifique, Saclay Plant Sciences)

  • Philippe Muller

    (Institut des Sciences du Végétal (ISV), UPR2355 Centre National de la Recherche Scientifique, Saclay Plant Sciences)

  • Esther Lechner

    (Institut de Biologie Moléculaire des Plantes (IBMP), UPR2357 Centre National de la Recherche Scientifique)

  • Pascal Genschik

    (Institut de Biologie Moléculaire des Plantes (IBMP), UPR2357 Centre National de la Recherche Scientifique)

  • Catherine Perrot-Rechenmann

    (Institut des Sciences du Végétal (ISV), UPR2355 Centre National de la Recherche Scientifique, Saclay Plant Sciences)

Abstract

Auxin is a major plant hormone that controls most aspects of plant growth and development. Auxin is perceived by two distinct classes of receptors: transport inhibitor response 1 (TIR1, or auxin-related F-box (AFB)) and auxin/indole-3-acetic acid (AUX/IAA) coreceptors, that control transcriptional responses to auxin, and the auxin-binding protein 1 (ABP1), that controls a wide variety of growth and developmental processes. To date, the mode of action of ABP1 is still poorly understood and its functional interaction with TIR1/AFB–AUX/IAA coreceptors remains elusive. Here we combine genetic and biochemical approaches to gain insight into the integration of these two pathways. We find that ABP1 is genetically upstream of TIR1/AFBs; ABP1 knockdown leads to an enhanced degradation of AUX/IAA repressors, independently of its effects on endocytosis, through the SCFTIR1/AFB E3 ubiquitin ligase pathway. Combining positive and negative regulation of SCF ubiquitin-dependent pathways might be a common mechanism conferring tight control of hormone-mediated responses.

Suggested Citation

  • Alexandre Tromas & Sébastien Paque & Vérène Stierlé & Anne-Laure Quettier & Philippe Muller & Esther Lechner & Pascal Genschik & Catherine Perrot-Rechenmann, 2013. "Auxin-Binding Protein 1 is a negative regulator of the SCFTIR1/AFB pathway," Nature Communications, Nature, vol. 4(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3496
    DOI: 10.1038/ncomms3496
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms3496
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms3496?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ryan P. Wurz & Huan Rui & Ken Dellamaggiore & Sudipa Ghimire-Rijal & Kaylee Choi & Kate Smither & Albert Amegadzie & Ning Chen & Xiaofen Li & Abhisek Banerjee & Qing Chen & Dane Mohl & Amit Vaish, 2023. "Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3496. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.