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Human gut microbiota community structures in urban and rural populations in Russia

Author

Listed:
  • Alexander V. Tyakht

    (Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia)

  • Elena S. Kostryukova

    (Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia)

  • Anna S. Popenko

    (Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia)

  • Maxim S. Belenikin

    (Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia)

  • Alexander V. Pavlenko

    (Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia)

  • Andrey K. Larin

    (Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia)

  • Irina Y. Karpova

    (Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia)

  • Oksana V. Selezneva

    (Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia)

  • Tatyana A. Semashko

    (Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia)

  • Elena A. Ospanova

    (Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia)

  • Vladislav V. Babenko

    (Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia)

  • Igor V. Maev

    (Moscow State University of Medicine and Dentistry, Delegatskaya 20-1, Moscow 127473, Russia)

  • Sergey V. Cheremushkin

    (Moscow State University of Medicine and Dentistry, Delegatskaya 20-1, Moscow 127473, Russia)

  • Yuriy A. Kucheryavyy

    (Moscow State University of Medicine and Dentistry, Delegatskaya 20-1, Moscow 127473, Russia)

  • Petr L. Shcherbakov

    (Central Scientific Institute of Gastroenterology, Shosse Entuziastov 86, Moscow 111123, Russia)

  • Vladimir B. Grinevich

    (Kirov Military Medical Academy, Lebedeva 6, Saint Petersburg 194175, Russia)

  • Oleg I. Efimov

    (Kirov Military Medical Academy, Lebedeva 6, Saint Petersburg 194175, Russia)

  • Evgenii I. Sas

    (Kirov Military Medical Academy, Lebedeva 6, Saint Petersburg 194175, Russia)

  • Rustam A. Abdulkhakov

    (Kazan’ State Medical University, Butlerova 49, Kazan’ 420012, Russia)

  • Sayar R. Abdulkhakov

    (Kazan' (Volga Region) Federal University, Kremlyovskaya 18, Kazan' 420008, Russia)

  • Elena A. Lyalyukova

    (Omsk State Medical Academy, Lenina 12, Omsk 644043, Russia)

  • Maria A. Livzan

    (Omsk State Medical Academy, Lenina 12, Omsk 644043, Russia)

  • Valentin V. Vlassov

    (Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences, Prospekt Akademika Lavrent'eva 8, Novosibirsk 630090, Russia)

  • Renad Z. Sagdeev

    (International Tomography Center of the Siberian Branch of the Russian Academy of Sciences, Institutskaya 3A, Novosibirsk 630090, Russia)

  • Vladislav V. Tsukanov

    (Scientific Research Institute of Medical Problems of the North, Partizana Zhelezniaka 3G, Krasnoyarsk 660022, Russia)

  • Marina F. Osipenko

    (Novosibirsk State Medical University, Krasny Prospect 52, Novosibirsk 630091, Russia)

  • Irina V. Kozlova

    (Saratov State Medical University, Bolshaya Kazachia 112, Saratov 410012, Russia)

  • Alexander V. Tkachev

    (Rostov State Medical University, Suvorova 118/50, Rostov-on-Don 344022, Russia)

  • Valery I. Sergienko

    (Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia)

  • Dmitry G. Alexeev

    (Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia
    Moscow Institute of Physics and Technology, Institutskii Per. 9, Moscow Region, Dolgoprudny 141700, Russia)

  • Vadim M. Govorun

    (Research Institute of Physico-Chemical Medicine, Malaya Pirogovskaya 1a, Moscow 119435, Russia
    Moscow Institute of Physics and Technology, Institutskii Per. 9, Moscow Region, Dolgoprudny 141700, Russia
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, GSP-7, Miklukho-Maklaya 16/10, Moscow 117997, Russia)

Abstract

The microbial community of the human gut has a crucial role in sustaining host homeostasis. High-throughput DNA sequencing has delineated the structural and functional configurations of gut metagenomes in world populations. The microbiota of the Russian population is of particular interest to researchers, because Russia encompasses a uniquely wide range of environmental conditions and ethnogeographical cohorts. Here we conduct a shotgun metagenomic analysis of gut microbiota samples from 96 healthy Russian adult subjects, which reveals novel microbial community structures. The communities from several rural regions display similarities within each region and are dominated by the bacterial taxa associated with the healthy gut. Functional analysis shows that the metabolic pathways exhibiting differential abundance in the novel types are primarily associated with the trade-off between the Bacteroidetes and Firmicutes phyla. The specific signatures of the Russian gut microbiota are likely linked to the host diet, cultural habits and socioeconomic status.

Suggested Citation

  • Alexander V. Tyakht & Elena S. Kostryukova & Anna S. Popenko & Maxim S. Belenikin & Alexander V. Pavlenko & Andrey K. Larin & Irina Y. Karpova & Oksana V. Selezneva & Tatyana A. Semashko & Elena A. Os, 2013. "Human gut microbiota community structures in urban and rural populations in Russia," Nature Communications, Nature, vol. 4(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3469
    DOI: 10.1038/ncomms3469
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    Cited by:

    1. Kumaraswamy Jeyaram & Leo Lahti & Sebastian Tims & Hans G. H. J. Heilig & Antonie H. Gelder & Willem M. Vos & Hauke Smidt & Erwin G. Zoetendal, 2025. "Fermented foods affect the seasonal stability of gut bacteria in an Indian rural population," Nature Communications, Nature, vol. 16(1), pages 1-18, December.

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