IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v4y2013i1d10.1038_ncomms3418.html
   My bibliography  Save this article

In vivo cardiac phase response curve elucidates human respiratory heart rate variability

Author

Listed:
  • Björn Kralemann

    (Institut für Pädagogik, Christian-Albrechts-Universität zu Kiel)

  • Matthias Frühwirth

    (Human Research Institute of Health Technology and Prevention Research)

  • Arkady Pikovsky

    (University of Potsdam)

  • Michael Rosenblum

    (University of Potsdam)

  • Thomas Kenner

    (Institute of Physiology, Medical University)

  • Jochen Schaefer

    (International Institute for Theoretical Cardiology)

  • Maximilian Moser

    (Human Research Institute of Health Technology and Prevention Research
    Institute of Physiology, Medical University)

Abstract

Recovering interaction of endogenous rhythms from observations is challenging, especially if a mathematical model explaining the behaviour of the system is unknown. The decisive information for successful reconstruction of the dynamics is the sensitivity of an oscillator to external influences, which is quantified by its phase response curve. Here we present a technique that allows the extraction of the phase response curve from a non-invasive observation of a system consisting of two interacting oscillators—in this case heartbeat and respiration—in its natural environment and under free-running conditions. We use this method to obtain the phase-coupling functions describing cardiorespiratory interactions and the phase response curve of 17 healthy humans. We show for the first time the phase at which the cardiac beat is susceptible to respiratory drive and extract the respiratory-related component of heart rate variability. This non-invasive method for the determination of phase response curves of coupled oscillators may find application in many scientific disciplines.

Suggested Citation

  • Björn Kralemann & Matthias Frühwirth & Arkady Pikovsky & Michael Rosenblum & Thomas Kenner & Jochen Schaefer & Maximilian Moser, 2013. "In vivo cardiac phase response curve elucidates human respiratory heart rate variability," Nature Communications, Nature, vol. 4(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3418
    DOI: 10.1038/ncomms3418
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms3418
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms3418?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Björn R H Blomqvist & Richard P Mann & David J T Sumpter, 2018. "Using Bayesian dynamical systems, model averaging and neural networks to determine interactions between socio-economic indicators," PLOS ONE, Public Library of Science, vol. 13(5), pages 1-23, May.
    2. Eddie Nijholt & Jorge Luis Ocampo-Espindola & Deniz Eroglu & István Z. Kiss & Tiago Pereira, 2022. "Emergent hypernetworks in weakly coupled oscillators," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    3. Bezruchko, B.P. & Ponomarenko, V.I. & Smirnov, D.A. & Sysoev, I.V. & Prokhorov, M.D., 2021. "Class-oriented techniques for reconstruction of dynamics from time series," Chaos, Solitons & Fractals, Elsevier, vol. 148(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3418. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.