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Changes in the regulation of cortical neurogenesis contribute to encephalization during amniote brain evolution

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  • Tadashi Nomura

    (Kyoto Prefectural University of Medicine
    Japan Science and Technology Agency, PRESTO)

  • Hitoshi Gotoh

    (Kyoto Prefectural University of Medicine)

  • Katsuhiko Ono

    (Kyoto Prefectural University of Medicine)

Abstract

The emergence of larger brains with large numbers of neurons is an evolutionary innovation in mammals and birds. However, the corresponding changes in cortical developmental programmes during amniote evolution are poorly understood. Here we examine the cortical development of Madagascar ground geckos, and report unique characteristics of their reptilian cortical progenitors. The rates of proliferation and neuronal differentiation in the gecko cortex are much lower than those in other amniotes. Notch signalling is highly activated in the gecko cortical progenitors, which provides a molecular basis for the low rate of cortical neurogenesis. Interestingly, multiple neuron subtypes are sequentially generated in the gecko cortex, similar to other amniotes. These results suggest that changes in the regulation of cortical neural progenitors have accelerated neurogenesis and provided encephalization in mammalian and archosaurian lineages. In addition, the temporal regulation for making cortical neuronal subtypes has evolved in a common ancestor(s) of amniotes.

Suggested Citation

  • Tadashi Nomura & Hitoshi Gotoh & Katsuhiko Ono, 2013. "Changes in the regulation of cortical neurogenesis contribute to encephalization during amniote brain evolution," Nature Communications, Nature, vol. 4(1), pages 1-12, October.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3206
    DOI: 10.1038/ncomms3206
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    Cited by:

    1. Annalisa Paolino & Elizabeth H. Haines & Evan J. Bailey & Dylan A. Black & Ching Moey & Fernando García-Moreno & Linda J. Richards & Rodrigo Suárez & Laura R. Fenlon, 2023. "Non-uniform temporal scaling of developmental processes in the mammalian cortex," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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