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B7-H5 costimulates human T cells via CD28H

Author

Listed:
  • Yuwen Zhu

    (Yale University School of Medicine
    Present address: Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA)

  • Sheng Yao

    (Yale University School of Medicine)

  • Bettina P. Iliopoulou

    (Massachusetts Institute of Technology)

  • Xue Han

    (Yale University School of Medicine)

  • Mathew M. Augustine

    (Johns Hopkins University School of Medicine)

  • Haiying Xu

    (Johns Hopkins University School of Medicine)

  • Ryan T. Phennicie

    (Massachusetts Institute of Technology)

  • Sarah J. Flies

    (Johns Hopkins University School of Medicine)

  • Megan Broadwater

    (Johns Hopkins University School of Medicine)

  • William Ruff

    (Johns Hopkins University School of Medicine)

  • Janis M. Taube

    (Johns Hopkins University School of Medicine)

  • Linghua Zheng

    (Yale University School of Medicine)

  • Liqun Luo

    (Yale University School of Medicine)

  • Gefeng Zhu

    (Yale University School of Medicine)

  • Jianzhu Chen

    (Massachusetts Institute of Technology)

  • Lieping Chen

    (Yale University School of Medicine
    Johns Hopkins University School of Medicine)

Abstract

The B7/CD28 family has profound modulatory effects in immune responses and constitutes an important target for the development of novel therapeutic drugs against human diseases. Here we describe a new CD28 homologue (CD28H) that has unique functions in the regulation of the human immune response and is absent in mice. CD28H is constitutively expressed on all naive T cells. Repetitive antigenic exposure, however, induces a complete loss of CD28H on many T cells, and CD28H negative T cells have a phenotype of terminal differentiation and senescence. After extensive screening in a receptor array, a B7-like molecule, B7 homologue 5 (B7-H5), was identified as a specific ligand for CD28H. B7-H5 is constitutively found in macrophages and could be induced on dendritic cells. The B7-H5/CD28H interaction selectively costimulates human T-cell growth and cytokine production via an AKT-dependent signalling cascade. Our study identifies a novel costimulatory pathway regulating human T-cell responses.

Suggested Citation

  • Yuwen Zhu & Sheng Yao & Bettina P. Iliopoulou & Xue Han & Mathew M. Augustine & Haiying Xu & Ryan T. Phennicie & Sarah J. Flies & Megan Broadwater & William Ruff & Janis M. Taube & Linghua Zheng & Liq, 2013. "B7-H5 costimulates human T cells via CD28H," Nature Communications, Nature, vol. 4(1), pages 1-12, October.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3043
    DOI: 10.1038/ncomms3043
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    Cited by:

    1. Hao Wang & R. Alejandro Sica & Gurbakhash Kaur & Phillip M. Galbo & Zhixin Jing & Christopher D. Nishimura & Xiaoxin Ren & Ankit Tanwar & Bijan Etemad-Gilbertson & Britta Will & Deyou Zheng & David Fo, 2024. "TMIGD2 is an orchestrator and therapeutic target on human acute myeloid leukemia stem cells," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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