IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v4y2013i1d10.1038_ncomms2895.html
   My bibliography  Save this article

Dll1 maintains quiescence of adult neural stem cells and segregates asymmetrically during mitosis

Author

Listed:
  • Daichi Kawaguchi

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
    Present address: Molecular Neurobiology Laboratory, The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, California 92037, USA)

  • Shohei Furutachi

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Hiroki Kawai

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

  • Katsuto Hozumi

    (Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan)

  • Yukiko Gotoh

    (Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan)

Abstract

Stem cells often divide asymmetrically to produce one stem cell and one differentiating cell, thus maintaining the stem cell pool. Although neural stem cells (NSCs) in the adult mouse subventricular zone have been suggested to divide asymmetrically, intrinsic cell fate determinants for asymmetric NSC division are largely unknown. Stem cell niches are important for stem cell maintenance, but the niche for the maintenance of adult quiescent NSCs has remained obscure. Here we show that the Notch ligand Delta-like 1 (Dll1) is required to maintain quiescent NSCs in the adult mouse subventricular zone. Dll1 protein is induced in activated NSCs and segregates to one daughter cell during mitosis. Dll1-expressing cells reside in close proximity to quiescent NSCs, suggesting a feedback signal for NSC maintenance by their sister cells and progeny. Our data suggest a model in which NSCs produce their own niche cells for their maintenance through asymmetric Dll1 inheritance at mitosis.

Suggested Citation

  • Daichi Kawaguchi & Shohei Furutachi & Hiroki Kawai & Katsuto Hozumi & Yukiko Gotoh, 2013. "Dll1 maintains quiescence of adult neural stem cells and segregates asymmetrically during mitosis," Nature Communications, Nature, vol. 4(1), pages 1-12, October.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2895
    DOI: 10.1038/ncomms2895
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms2895
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms2895?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Dylan Scott Lykke Harwood & Vilde Pedersen & Nicolai Schou Bager & Ane Yde Schmidt & Tobias Overlund Stannius & Aušrinė Areškevičiūtė & Knud Josefsen & Dorte Schou Nørøxe & David Scheie & Hannah Rosta, 2024. "Glioblastoma cells increase expression of notch signaling and synaptic genes within infiltrated brain tissue," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Yujin Harada & Mayumi Yamada & Itaru Imayoshi & Ryoichiro Kageyama & Yutaka Suzuki & Takaaki Kuniya & Shohei Furutachi & Daichi Kawaguchi & Yukiko Gotoh, 2021. "Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    3. David Morizet & Isabelle Foucher & Alessandro Alunni & Laure Bally-Cuif, 2024. "Reconstruction of macroglia and adult neurogenesis evolution through cross-species single-cell transcriptomic analyses," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2895. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.