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Draft genome sequence of the Tibetan antelope

Author

Listed:
  • Ri-Li Ge

    (Key Laboratory for High Altitude Medicine of Ministry of Chinese Education and Research Center for High Altitude Medicine, Qinghai University)

  • Qingle Cai

    (BGI-Shenzhen)

  • Yong-Yi Shen

    (State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences
    State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University)

  • A San

    (BGI-Shenzhen)

  • Lan Ma

    (Key Laboratory for High Altitude Medicine of Ministry of Chinese Education and Research Center for High Altitude Medicine, Qinghai University)

  • Yong Zhang

    (BGI-Shenzhen)

  • Xin Yi

    (BGI-Shenzhen)

  • Yan Chen

    (BGI-Shenzhen)

  • Lingfeng Yang

    (BGI-Shenzhen)

  • Ying Huang

    (BGI-Shenzhen)

  • Rongjun He

    (BGI-Shenzhen)

  • Yuanyuan Hui

    (BGI-Shenzhen)

  • Meirong Hao

    (BGI-Shenzhen)

  • Yue Li

    (BGI-Shenzhen)

  • Bo Wang

    (BGI-Shenzhen)

  • Xiaohua Ou

    (BGI-Shenzhen)

  • Jiaohui Xu

    (BGI-Shenzhen)

  • Yongfen Zhang

    (BGI-Shenzhen)

  • Kui Wu

    (BGI-Shenzhen)

  • Chunyu Geng

    (BGI-Shenzhen)

  • Weiping Zhou

    (State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences)

  • Taicheng Zhou

    (State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences)

  • David M. Irwin

    (State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences
    University of Toronto)

  • Yingzhong Yang

    (Key Laboratory for High Altitude Medicine of Ministry of Chinese Education and Research Center for High Altitude Medicine, Qinghai University)

  • Liu Ying

    (Affiliated Hospital of Qinghai University)

  • Haihua Bao

    (Affiliated Hospital of Qinghai University)

  • Jaebum Kim

    (Institute for Genomic Biology, University of Illinois at Urbana-Champaign
    Konkuk University)

  • Denis M. Larkin

    (Institute of Biological, Environmental and Rural Sciences, Aberystwyth University)

  • Jian Ma

    (Institute for Genomic Biology, University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

  • Harris A. Lewin

    (University of California)

  • Jinchuan Xing

    (Eccles Institute of Human Genetics, University of Utah School of Medicine)

  • Roy N. Platt

    (Molecular Biology, Entomology and Plant Pathology, Mississippi State University)

  • David A. Ray

    (Molecular Biology, Entomology and Plant Pathology, Mississippi State University)

  • Loretta Auvil

    (National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign)

  • Boris Capitanu

    (National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign)

  • Xiufeng Zhang

    (Gerumud Hospital, Gerumud)

  • Guojie Zhang

    (BGI-Shenzhen)

  • Robert W. Murphy

    (State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences
    Centre for Biodiversity and Conservation Biology, Royal Ontario Museum)

  • Jun Wang

    (BGI-Shenzhen
    University of Copenhagen
    King Abdulaziz University)

  • Ya-Ping Zhang

    (State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, The Chinese Academy of Sciences)

  • Jian Wang

    (BGI-Shenzhen)

Abstract

The Tibetan antelope (Pantholops hodgsonii) is endemic to the extremely inhospitable high-altitude environment of the Qinghai-Tibetan Plateau, a region that has a low partial pressure of oxygen and high ultraviolet radiation. Here we generate a draft genome of this artiodactyl and use it to detect the potential genetic bases of highland adaptation. Compared with other plain-dwelling mammals, the genome of the Tibetan antelope shows signals of adaptive evolution and gene-family expansion in genes associated with energy metabolism and oxygen transmission. Both the highland American pika, and the Tibetan antelope have signals of positive selection for genes involved in DNA repair and the production of ATPase. Genes associated with hypoxia seem to have experienced convergent evolution. Thus, our study suggests that common genetic mechanisms might have been utilized to enable high-altitude adaptation.

Suggested Citation

  • Ri-Li Ge & Qingle Cai & Yong-Yi Shen & A San & Lan Ma & Yong Zhang & Xin Yi & Yan Chen & Lingfeng Yang & Ying Huang & Rongjun He & Yuanyuan Hui & Meirong Hao & Yue Li & Bo Wang & Xiaohua Ou & Jiaohui , 2013. "Draft genome sequence of the Tibetan antelope," Nature Communications, Nature, vol. 4(1), pages 1-7, October.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2860
    DOI: 10.1038/ncomms2860
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    Cited by:

    1. Pavel V. Panteleev & Eugene B. Pichkur & Roman N. Kruglikov & Alena Paleskava & Olga V. Shulenina & Ilia A. Bolosov & Ivan V. Bogdanov & Victoria N. Safronova & Sergey V. Balandin & Valeriya I. Marina, 2024. "Rumicidins are a family of mammalian host-defense peptides plugging the 70S ribosome exit tunnel," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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