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Trapping red blood cells in living animals using optical tweezers

Author

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  • Min-Cheng Zhong

    (University of Science and Technology of China)

  • Xun-Bin Wei

    (University of Science and Technology of China
    Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University)

  • Jin-Hua Zhou

    (University of Science and Technology of China)

  • Zi-Qiang Wang

    (University of Science and Technology of China)

  • Yin-Mei Li

    (University of Science and Technology of China)

Abstract

The recent development of non-invasive imaging techniques has enabled the visualization of molecular events underlying cellular processes in live cells. Although microscopic objects can be readily manipulated at the cellular level, additional physiological insight is likely to be gained by manipulation of cells in vivo, which has not been achieved so far. Here we use infrared optical tweezers to trap and manipulate red blood cells within subdermal capillaries in living mice. We realize a non-contact micro-operation that results in the clearing of a blocked microvessel. Furthermore, we estimate the optical trap stiffness in the capillary. Our work expands the application of optical tweezers to the study of live cell dynamics in animals.

Suggested Citation

  • Min-Cheng Zhong & Xun-Bin Wei & Jin-Hua Zhou & Zi-Qiang Wang & Yin-Mei Li, 2013. "Trapping red blood cells in living animals using optical tweezers," Nature Communications, Nature, vol. 4(1), pages 1-7, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2786
    DOI: 10.1038/ncomms2786
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    Cited by:

    1. Ruoqin Zhang & Xichuan Zhao & Jinzhi Li & Di Zhou & Honglian Guo & Zhi-yuan Li & Feng Li, 2024. "Programmable photoacoustic patterning of microparticles in air," Nature Communications, Nature, vol. 15(1), pages 1-8, December.

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