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Basophils are required for the induction of Th2 immunity to haptens and peptide antigens

Author

Listed:
  • Atsushi Otsuka

    (Kyoto University Graduate School of Medicine
    Center for Innovation in Immunoregulative Technology and Therapeutics, Kyoto University Graduate School of Medicine)

  • Saeko Nakajima

    (Kyoto University Graduate School of Medicine)

  • Masato Kubo

    (Laboratory for Cytokine Regulation, Integrative Medical Science (IMS), RIKEN Yokohama Institute
    Research Institute for Biomedical Science, Tokyo University of Science 2669 Yamazaki)

  • Gyohei Egawa

    (Kyoto University Graduate School of Medicine)

  • Tetsuya Honda

    (Kyoto University Graduate School of Medicine)

  • Akihiko Kitoh

    (Kyoto University Graduate School of Medicine)

  • Takashi Nomura

    (Kyoto University Graduate School of Medicine)

  • Sho Hanakawa

    (Kyoto University Graduate School of Medicine)

  • Catharina Sagita Moniaga

    (Kyoto University Graduate School of Medicine)

  • Bongju Kim

    (Center for Innovation in Immunoregulative Technology and Therapeutics, Kyoto University Graduate School of Medicine)

  • Satoshi Matsuoka

    (Center for Innovation in Immunoregulative Technology and Therapeutics, Kyoto University Graduate School of Medicine)

  • Takeshi Watanabe

    (Center for Innovation in Immunoregulative Technology and Therapeutics, Kyoto University Graduate School of Medicine)

  • Yoshiki Miyachi

    (Kyoto University Graduate School of Medicine)

  • Kenji Kabashima

    (Kyoto University Graduate School of Medicine)

Abstract

The relative contributions of basophils and dendritic cells in Th2 skewing to foreign antigen exposure remain unclear. Here we report the ability of basophils to induce Th2 polarization upon epicutaneous sensitization with different antigens using basophil conditionally depleted Bas TRECK transgenic mice. Basophils are responsible for Th2 skewing to haptens and peptide antigens, but not protein antigens in vivo. Consistent with this, basophils cannot take up or process ovalbumin protein in significant quantities, but present ovalbumin peptide to T cells for Th2 differentiation via major histocompatibility complex class II. Intriguingly, basophils promote Th2 skewing upon ovalbumin protein exposure in the presence of dendritic cells. Taken together, our results suggest that basophils alone are able to induce Th2 skewing with haptens and peptide antigens but require dendritic cells for the induction of Th2 for protein antigens upon epicutaneous immunization.

Suggested Citation

  • Atsushi Otsuka & Saeko Nakajima & Masato Kubo & Gyohei Egawa & Tetsuya Honda & Akihiko Kitoh & Takashi Nomura & Sho Hanakawa & Catharina Sagita Moniaga & Bongju Kim & Satoshi Matsuoka & Takeshi Watana, 2013. "Basophils are required for the induction of Th2 immunity to haptens and peptide antigens," Nature Communications, Nature, vol. 4(1), pages 1-9, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2740
    DOI: 10.1038/ncomms2740
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    Cited by:

    1. John TCHEN & Quentin SIMON & Léa CHAPART & Morgane K. THAMINY & Shamila VIBHUSHAN & Loredana SAVEANU & Yasmine LAMRI & Fanny SAIDOUNE & Emeline PACREAU & Christophe PELLEFIGUES & Julie BEX-COUDRAT & H, 2024. "PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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