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Mouse urinary peptides provide a molecular basis for genotype discrimination by nasal sensory neurons

Author

Listed:
  • Theo Sturm

    (Institute for Cell Biology, University of Tübingen)

  • Trese Leinders-Zufall

    (University of Saarland, School of Medicine)

  • Boris Maček

    (Proteome Center Tuebingen, Institute for Cell Biology, University of Tübingen)

  • Mathias Walzer

    (Institute for Cell Biology, University of Tübingen
    Applied Bioinformatics, Center for Bioinformatics and Quantitative Biology Center, University of Tübingen)

  • Stephan Jung

    (Proteome Center Tuebingen, Institute for Cell Biology, University of Tübingen)

  • Beate Pömmerl

    (Institute for Cell Biology, University of Tübingen)

  • Stefan Stevanović

    (Institute for Cell Biology, University of Tübingen)

  • Frank Zufall

    (University of Saarland, School of Medicine)

  • Peter Overath

    (Institute for Cell Biology, University of Tübingen)

  • Hans-Georg Rammensee

    (Institute for Cell Biology, University of Tübingen)

Abstract

Selected groups of peptides, including those that are presented by major histocompatibility complex (MHC) proteins, have been proposed to transmit information to the olfactory system of vertebrates via their ability to stimulate chemosensory neurons. However, the lack of knowledge about such peptides in natural sources accessible for nasal recognition has been a major barrier for this hypothesis. Here we analyse urinary peptides from selected mouse strains with respect to genotype-related individual differences. We discover many abundant peptides with single amino-acid variations corresponding to genomic differences. The polymorphism of major urinary proteins is reflected by variations in prominent urinary peptides. We also demonstrate an MHC-dependent peptide (SIINFEKL) occurring at very low concentrations in mouse urine. Chemoreceptive neurons in the vomeronasal organ detect and discriminate single amino-acid variation peptides as well as SIINFEKL. Hence, urinary peptides represent a real-time sampling of the expressed genome available for chemosensory assessment by other individuals.

Suggested Citation

  • Theo Sturm & Trese Leinders-Zufall & Boris Maček & Mathias Walzer & Stephan Jung & Beate Pömmerl & Stefan Stevanović & Frank Zufall & Peter Overath & Hans-Georg Rammensee, 2013. "Mouse urinary peptides provide a molecular basis for genotype discrimination by nasal sensory neurons," Nature Communications, Nature, vol. 4(1), pages 1-10, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2610
    DOI: 10.1038/ncomms2610
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    1. Lisa Bertrand & Annika Nelde & Bertha Cecilia Ramirez & Isabelle Hatin & Hugo Arbes & Pauline François & Stéphane Demais & Emmanuel Labaronne & Didier Decimo & Laura Guiguettaz & Sylvie Grégoire & Ann, 2025. "Unveiling conserved HIV-1 open reading frames encoding T cell antigens using ribosome profiling," Nature Communications, Nature, vol. 16(1), pages 1-18, December.

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