IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v4y2013i1d10.1038_ncomms2515.html
   My bibliography  Save this article

Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels

Author

Listed:
  • Lucian Medrihan

    (Istituto Italiano di Tecnologia, Via Morego 30
    University of Genoa, Viale Benedetto XV 3)

  • Fabrizia Cesca

    (Istituto Italiano di Tecnologia, Via Morego 30)

  • Andrea Raimondi

    (Istituto Italiano di Tecnologia, Via Morego 30)

  • Gabriele Lignani

    (Istituto Italiano di Tecnologia, Via Morego 30)

  • Pietro Baldelli

    (Istituto Italiano di Tecnologia, Via Morego 30
    University of Genoa, Viale Benedetto XV 3)

  • Fabio Benfenati

    (Istituto Italiano di Tecnologia, Via Morego 30
    University of Genoa, Viale Benedetto XV 3)

Abstract

In the central nervous system, most synapses show a fast mode of neurotransmitter release known as synchronous release followed by a phase of asynchronous release, which extends over tens of milliseconds to seconds. Synapsin II (SYN2) is a member of the multigene synapsin family (SYN1/2/3) of synaptic vesicle phosphoproteins that modulate synaptic transmission and plasticity, and are mutated in epileptic patients. Here we report that inhibitory synapses of the dentate gyrus of Syn II knockout mice display an upregulation of synchronous neurotransmitter release and a concomitant loss of delayed asynchronous release. Syn II promotes γ-aminobutyric acid asynchronous release in a Ca2+-dependent manner by a functional interaction with presynaptic Ca2+ channels, revealing a new role in synaptic transmission for synapsins.

Suggested Citation

  • Lucian Medrihan & Fabrizia Cesca & Andrea Raimondi & Gabriele Lignani & Pietro Baldelli & Fabio Benfenati, 2013. "Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels," Nature Communications, Nature, vol. 4(1), pages 1-13, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2515
    DOI: 10.1038/ncomms2515
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms2515
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms2515?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Shanley F. Longfield & Rachel S. Gormal & Matis Feller & Pierre Parutto & Jürgen Reingruber & Tristan P. Wallis & Merja Joensuu & George J. Augustine & Ramón Martínez-Mármol & David Holcman & Frédéric, 2024. "Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Israel Aguilar-Ordoñez & Fernando Pérez-Villatoro & Humberto García-Ortiz & Francisco Barajas-Olmos & Judith Ballesteros-Villascán & Ram González-Buenfil & Cristobal Fresno & Alejandro Garcíarrubio & , 2021. "Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights," PLOS ONE, Public Library of Science, vol. 16(4), pages 1-19, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2515. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.