IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v4y2013i1d10.1038_ncomms2364.html
   My bibliography  Save this article

Signalling properties of inorganic polyphosphate in the mammalian brain

Author

Listed:
  • Kira M. Holmström

    (UCL Institute of Neurology)

  • Nephtali Marina

    (Physiology and Pharmacology, University College London)

  • Artyom Y. Baev

    (UCL Institute of Neurology)

  • Nicholas W. Wood

    (UCL Institute of Neurology)

  • Alexander V. Gourine

    (Physiology and Pharmacology, University College London)

  • Andrey Y. Abramov

    (UCL Institute of Neurology)

Abstract

Inorganic polyphosphate is known to be present in the mammalian brain at micromolar concentrations. Here we show that polyphosphate may act as a gliotransmitter, mediating communication between astrocytes. It is released by astrocytes in a calcium-dependent manner and signals to neighbouring astrocytes through P2Y1 purinergic receptors, activation of phospholipase C and release of calcium from the intracellular stores. In primary neuroglial cultures, application of polyP triggers release of endogenous polyphosphate from astrocytes while neurons take it up. In vivo, central actions of polyphosphate at the level of the brainstem include profound increases in key homeostatic physiological activities, such as breathing, central sympathetic outflow and the arterial blood pressure. Together, these results suggest a role for polyphosphate as a mediator of astroglial signal transmission in the mammalian brain.

Suggested Citation

  • Kira M. Holmström & Nephtali Marina & Artyom Y. Baev & Nicholas W. Wood & Alexander V. Gourine & Andrey Y. Abramov, 2013. "Signalling properties of inorganic polyphosphate in the mammalian brain," Nature Communications, Nature, vol. 4(1), pages 1-8, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2364
    DOI: 10.1038/ncomms2364
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms2364
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms2364?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Zeyuan Guan & Juan Chen & Ruiwen Liu & Yanke Chen & Qiong Xing & Zhangmeng Du & Meng Cheng & Jianjian Hu & Wenhui Zhang & Wencong Mei & Beijing Wan & Qiang Wang & Jie Zhang & Peng Cheng & Huanyu Cai &, 2023. "The cytoplasmic synthesis and coupled membrane translocation of eukaryotic polyphosphate by signal-activated VTC complex," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2364. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.