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Delivery of chemotherapeutic drugs in tumour cell-derived microparticles

Author

Listed:
  • Ke Tang

    (Tongji Medical College, Huazhong University of Science and Technology
    Tongji Medical College, Huazhong University of Science and Technology)

  • Yi Zhang

    (Tongji Medical College, Huazhong University of Science and Technology)

  • Huafeng Zhang

    (Tongji Medical College, Huazhong University of Science and Technology)

  • Pingwei Xu

    (Tongji Medical College, Huazhong University of Science and Technology)

  • Jing Liu

    (Tongji Medical College, Huazhong University of Science and Technology)

  • Jingwei Ma

    (Tongji Medical College, Huazhong University of Science and Technology)

  • Meng Lv

    (Tongji Medical College, Huazhong University of Science and Technology)

  • Dapeng Li

    (Tongji Medical College, Huazhong University of Science and Technology)

  • Foad Katirai

    (Tongji Medical College, Huazhong University of Science and Technology)

  • Guan-Xin Shen

    (Tongji Medical College, Huazhong University of Science and Technology)

  • Guimei Zhang

    (Tongji Medical College, Huazhong University of Science and Technology)

  • Zuo-Hua Feng

    (Tongji Medical College, Huazhong University of Science and Technology)

  • Duyun Ye

    (Tongji Medical College, Huazhong University of Science and Technology)

  • Bo Huang

    (Tongji Medical College, Huazhong University of Science and Technology
    Chinese Academy of Medical Sciences)

Abstract

Cellular microparticles are vesicular plasma membrane fragments with a diameter of 100–1,000 nanometres that are shed by cells in response to various physiological and artificial stimuli. Here we demonstrate that tumour cell-derived microparticles can be used as vectors to deliver chemotherapeutic drugs. We show that tumour cells incubated with chemotherapeutic drugs package these drugs into microparticles, which can be collected and used to effectively kill tumour cells in murine tumour models without typical side effects. We describe several mechanisms involved in this process, including uptake of drug-containing microparticles by tumour cells, synthesis of additional drug-packaging microparticles by these cells that contribute to the cytotoxic effect and the inhibition of drug efflux from tumour cells. This study highlights a novel drug delivery strategy with potential clinical application.

Suggested Citation

  • Ke Tang & Yi Zhang & Huafeng Zhang & Pingwei Xu & Jing Liu & Jingwei Ma & Meng Lv & Dapeng Li & Foad Katirai & Guan-Xin Shen & Guimei Zhang & Zuo-Hua Feng & Duyun Ye & Bo Huang, 2012. "Delivery of chemotherapeutic drugs in tumour cell-derived microparticles," Nature Communications, Nature, vol. 3(1), pages 1-11, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms2282
    DOI: 10.1038/ncomms2282
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    Cited by:

    1. Xin Li & Tuying Yong & Zhaohan Wei & Nana Bie & Xiaoqiong Zhang & Guiting Zhan & Jianye Li & Jiaqi Qin & Jingjing Yu & Bixiang Zhang & Lu Gan & Xiangliang Yang, 2022. "Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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