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Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region

Author

Listed:
  • Yosuke Niibori

    (Program in Neurosciences and Mental Health, The Hospital for Sick Children)

  • Tzong-Shiue Yu

    (Program in Neurosciences and Mental Health, The Hospital for Sick Children)

  • Jonathan R. Epp

    (Program in Neurosciences and Mental Health, The Hospital for Sick Children)

  • Katherine G. Akers

    (Program in Neurosciences and Mental Health, The Hospital for Sick Children)

  • Sheena A. Josselyn

    (Program in Neurosciences and Mental Health, The Hospital for Sick Children
    University of Toronto)

  • Paul W. Frankland

    (Program in Neurosciences and Mental Health, The Hospital for Sick Children
    University of Toronto)

Abstract

Different places may share common features, but are coded by distinct populations of CA3 neurons in the hippocampus. Here we show that chemical or genetic suppression of adult neurogenesis in the hippocampus impairs this population-based coding of similar (but not dissimilar) contexts. These data provide a neural basis for impaired spatial discrimination following ablation of adult neurogenesis, and support the proposal that adult neurogenesis regulates the efficiency of a pattern separation process in the hippocampus.

Suggested Citation

  • Yosuke Niibori & Tzong-Shiue Yu & Jonathan R. Epp & Katherine G. Akers & Sheena A. Josselyn & Paul W. Frankland, 2012. "Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region," Nature Communications, Nature, vol. 3(1), pages 1-7, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms2261
    DOI: 10.1038/ncomms2261
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    Cited by:

    1. M. Agustina Frechou & Sunaina S. Martin & Kelsey D. McDermott & Evan A. Huaman & Şölen Gökhan & Wolfgang A. Tomé & Ruben Coen-Cagli & J. Tiago Gonçalves, 2024. "Adult neurogenesis improves spatial information encoding in the mouse hippocampus," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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