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Preotic neural crest cells contribute to coronary artery smooth muscle involving endothelin signalling

Author

Listed:
  • Yuichiro Arima

    (Graduate School of Medicine, University of Tokyo)

  • Sachiko Miyagawa-Tomita

    (Medical Research Institute, Tokyo Women’s Medical University)

  • Kazuhiro Maeda

    (Medical Research Institute, Tokyo Women’s Medical University)

  • Rieko Asai

    (Graduate School of Medicine, University of Tokyo)

  • Daiki Seya

    (Graduate School of Medicine, University of Tokyo)

  • Maryline Minoux

    (Friedrich Miescher Institute for Biomedical Research
    Faculté de chirurgie dentaire, 1, place de l'hpital)

  • Filippo M. Rijli

    (Friedrich Miescher Institute for Biomedical Research
    University of Basel)

  • Koichi Nishiyama

    (Graduate School of Medicine, University of Tokyo)

  • Ki-Sung Kim

    (Graduate School of Medicine, University of Tokyo)

  • Yasunobu Uchijima

    (Graduate School of Medicine, University of Tokyo)

  • Hisao Ogawa

    (Faculty of Life Sciences, Kumamoto University)

  • Yukiko Kurihara

    (Graduate School of Medicine, University of Tokyo)

  • Hiroki Kurihara

    (Graduate School of Medicine, University of Tokyo)

Abstract

Neural crest cells constitute a multipotent cell population that gives rise to diverse cell lineages. The neural crest arising from the postotic hindbrain is known as the ‘cardiac’ neural crest, and contributes to the great vessels and outflow tract endocardial cushions, but the neural crest contribution to structures within the heart remains largely controversial. Here we demonstrate that neural crest cells from the preotic region migrate into the heart and differentiate into coronary artery smooth muscle cells. Preotic neural crest cells preferentially distribute to the conotruncal region and interventricular septum. Ablation of the preotic neural crest causes abnormalities in coronary septal branch and orifice formation. Mice and chicks lacking endothelin signalling show similar abnormalities in the coronary artery, indicating its involvement in neural crest-dependent coronary artery formation. This is the first report that reveals the preotic neural crest contribution to heart development and smooth muscle heterogeneity within a coronary artery.

Suggested Citation

  • Yuichiro Arima & Sachiko Miyagawa-Tomita & Kazuhiro Maeda & Rieko Asai & Daiki Seya & Maryline Minoux & Filippo M. Rijli & Koichi Nishiyama & Ki-Sung Kim & Yasunobu Uchijima & Hisao Ogawa & Yukiko Kur, 2012. "Preotic neural crest cells contribute to coronary artery smooth muscle involving endothelin signalling," Nature Communications, Nature, vol. 3(1), pages 1-11, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms2258
    DOI: 10.1038/ncomms2258
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    Cited by:

    1. Christopher Bono & Yang Liu & Alexander Ferrena & Aneesa Valentine & Deyou Zheng & Bernice E. Morrow, 2023. "Single-cell transcriptomics uncovers a non-autonomous Tbx1-dependent genetic program controlling cardiac neural crest cell development," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Yong-Won Shin & Keun-Hwa Jung & Jeong-Min Kim & Young Dae Cho & Soon-Tae Lee & Kon Chu & Manho Kim & Sang Kun Lee & Moon Hee Han & Jae-Kyu Roh, 2014. "Echocardiographic Evidence of Innate Aortopathy in the Human Intracranial Aneurysm," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-7, June.

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