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A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides

Author

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  • Zhiwei Zhu

    (Dalian Institute of Chemical Physics, CAS
    Graduate University of Chinese Academy of Sciences)

  • Sufang Zhang

    (Dalian Institute of Chemical Physics, CAS
    Dalian National Laboratory for Clean Energy)

  • Hongwei Liu

    (Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, CAS)

  • Hongwei Shen

    (Dalian Institute of Chemical Physics, CAS
    Dalian National Laboratory for Clean Energy)

  • Xinping Lin

    (Dalian Institute of Chemical Physics, CAS
    Graduate University of Chinese Academy of Sciences)

  • Fan Yang

    (Dalian Institute of Chemical Physics, CAS
    School of Biological Engineering, Dalian Polytechnic University, 1 Qinggongyuan, Dalian 116034, China.)

  • Yongjin J. Zhou

    (Dalian Institute of Chemical Physics, CAS
    Graduate University of Chinese Academy of Sciences)

  • Guojie Jin

    (Dalian Institute of Chemical Physics, CAS
    Graduate University of Chinese Academy of Sciences)

  • Mingliang Ye

    (Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, CAS)

  • Hanfa Zou

    (Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, CAS)

  • Zongbao K. Zhao

    (Dalian Institute of Chemical Physics, CAS
    Dalian National Laboratory for Clean Energy)

Abstract

Triacylglycerols are among the most attractive alternative raw materials for biofuel development. Current oil plant-based technologies are limited in terms of triacylglycerol production capacity and rate. These limitations may be circumvented by biotransformation of carbohydrates into lipids; however, our understanding of microbial oleaginicity remains limited. Here we present the results of a multi-omic analysis of Rhodosporidium toruloides, a robust triacylglycerol-producing fungus. The assembly of genome and transcriptome sequencing data reveals a genome of 20.2 Mb containing 8,171 protein-coding genes, the majority of which have multiple introns. Genes including a novel fatty acid synthase are predicted to participate in metabolic pathways absent in non-oleaginous yeasts. Transcriptomic and proteomic data suggest that lipid accumulation under nitrogen-limited conditions correlates with the induction of lipogenesis, nitrogenous compound recycling, macromolecule metabolism and autophagy. The multi-omic map of R. toruloides therefore provides a valuable resource for efforts to rationally engineer lipid-production pathways.

Suggested Citation

  • Zhiwei Zhu & Sufang Zhang & Hongwei Liu & Hongwei Shen & Xinping Lin & Fan Yang & Yongjin J. Zhou & Guojie Jin & Mingliang Ye & Hanfa Zou & Zongbao K. Zhao, 2012. "A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides," Nature Communications, Nature, vol. 3(1), pages 1-12, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms2112
    DOI: 10.1038/ncomms2112
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    Cited by:

    1. Rahul Saini & Krishnamoorthy Hegde & Carlos Saul Osorio-Gonzalez & Satinder Kaur Brar & Pierre Vezina, 2020. "Evaluating the Potential of Rhodosporidium toruloides -1588 for High Lipid Production Using Undetoxified Wood Hydrolysate as a Carbon Source," Energies, MDPI, vol. 13(22), pages 1-14, November.
    2. Chen, Lu & Zhang, Yu & Liu, Guang-Lei & Chi, Zhe & Hu, Zhong & Chi, Zhen-Ming, 2020. "Cellular lipid production by the fatty acid synthase-duplicated Lipomyces kononenkoae BF1S57 strain for biodiesel making," Renewable Energy, Elsevier, vol. 151(C), pages 707-714.

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