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The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation

Author

Listed:
  • Francisco Ferrezuelo

    (IRBLleida-UdL)

  • Neus Colomina

    (IRBLleida-UdL)

  • Alida Palmisano

    (The Microsoft Research-University of Trento Centre for Computational and Systems Biology
    Virginia Polytechnic Institute and State University)

  • Eloi Garí

    (IRBLleida-UdL)

  • Carme Gallego

    (Institut de Biologia Molecular de Barcelona, CSIC)

  • Attila Csikász-Nagy

    (The Microsoft Research-University of Trento Centre for Computational and Systems Biology)

  • Martí Aldea

    (Institut de Biologia Molecular de Barcelona, CSIC)

Abstract

Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size control, cell volume at Start displays great individual variability even under constant conditions. Here we show that cell size at Start is robustly set at a single-cell level by the volume growth rate in G1, which explains the observed variability. We find that this growth-rate-dependent sizer is intimately hardwired into the Start network and the Ydj1 chaperone is key for setting cell size as a function of the individual growth rate. Mathematical modelling and experimental data indicate that a growth-rate-dependent sizer is sufficient to ensure size homeostasis and, as a remarkable advantage over a rigid sizer mechanism, it reduces noise in G1 length and provides an immediate solution for size adaptation to external conditions at a population level.

Suggested Citation

  • Francisco Ferrezuelo & Neus Colomina & Alida Palmisano & Eloi Garí & Carme Gallego & Attila Csikász-Nagy & Martí Aldea, 2012. "The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation," Nature Communications, Nature, vol. 3(1), pages 1-11, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms2015
    DOI: 10.1038/ncomms2015
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    Cited by:

    1. Andreas P. Cuny & K. Tanuj Sapra & David Martinez-Martin & Gotthold Fläschner & Jonathan D. Adams & Sascha Martin & Christoph Gerber & Fabian Rudolf & Daniel J. Müller, 2022. "High-resolution mass measurements of single budding yeast reveal linear growth segments," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. G. Yahya & P. Menges & P. S. Amponsah & D. A. Ngandiri & D. Schulz & A. Wallek & N. Kulak & M. Mann & P. Cramer & V. Savage & M. Räschle & Z. Storchova, 2022. "Sublinear scaling of the cellular proteome with ploidy," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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