IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v3y2012i1d10.1038_ncomms1854.html
   My bibliography  Save this article

An atlas of DNA methylomes in porcine adipose and muscle tissues

Author

Listed:
  • Mingzhou Li

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Honglong Wu

    (BGI-Shenzhen)

  • Zonggang Luo

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University
    Southwest University at Rongchang)

  • Yudong Xia

    (BGI-Shenzhen)

  • Jiuqiang Guan

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Tao Wang

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Yiren Gu

    (Sichuan Animal Science Academy)

  • Lei Chen

    (Chongqing Academy of Animal Science)

  • Kai Zhang

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University
    Present address: Sichuan Academy of Grassland Science, Chengdu, Sichuan 610000, China;)

  • Jideng Ma

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Yingkai Liu

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Zhijun Zhong

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Jing Nie

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Shuling Zhou

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Zhiping Mu

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Xiaoyan Wang

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Jingjing Qu

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Long Jing

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Huiyu Wang

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Shujia Huang

    (BGI-Shenzhen)

  • Na Yi

    (BGI-Shenzhen)

  • Zhe Wang

    (BGI-Shenzhen)

  • Dongxing Xi

    (BGI-Shenzhen)

  • Juan Wang

    (BGI-Shenzhen)

  • Guangliang Yin

    (BGI-Shenzhen)

  • Li Wang

    (BGI-Shenzhen)

  • Ning Li

    (BGI-Shenzhen)

  • Zhi Jiang

    (BGI-Shenzhen)

  • Qiulei Lang

    (LC-Bio)

  • Huasheng Xiao

    (National Engineering Center for Biochip at Shanghai)

  • Anan Jiang

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Li Zhu

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Yanzhi Jiang

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Guoqing Tang

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Miaomiao Mai

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Surong Shuai

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Ning Li

    (State Key Laboratory for Agrobiotechnology, China Agricultural University)

  • Kui Li

    (Institute of Animal Science, Chinese Academy of Agricultural Sciences)

  • Jinyong Wang

    (Chongqing Academy of Animal Science)

  • Xiuqing Zhang

    (BGI-Shenzhen)

  • Yingrui Li

    (BGI-Shenzhen)

  • Haosi Chen

    (University of Houston)

  • Xiaolian Gao

    (University of Houston)

  • Graham S. Plastow

    (Food and Nutritional Science, University of Alberta)

  • Stephen Beck

    (Medical Genomics, UCL Cancer Institute, University College London)

  • Huanming Yang

    (BGI-Shenzhen)

  • Jian Wang

    (BGI-Shenzhen)

  • Jun Wang

    (BGI-Shenzhen)

  • Xuewei Li

    (Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University)

  • Ruiqiang Li

    (BGI-Shenzhen
    Present address: Peking-Tsinghua Center for Life Sciences, Biodynamic Optical Imaging Center and School of Life Sciences, Peking University, Beijing 100871, China.)

Abstract

It is evident that epigenetic factors, especially DNA methylation, have essential roles in obesity development. Here, using pig as a model, we investigate the systematic association between DNA methylation and obesity. We sample eight variant adipose and two distinct skeletal muscle tissues from three pig breeds living within comparable environments but displaying distinct fat level. We generate 1,381 Gb of sequence data from 180 methylated DNA immunoprecipitation libraries, and provide a genome-wide DNA methylation map as well as a gene expression map for adipose and muscle studies. The analysis shows global similarity and difference among breeds, sexes and anatomic locations, and identifies the differentially methylated regions. The differentially methylated regions in promoters are highly associated with obesity development via expression repression of both known obesity-related genes and novel genes. This comprehensive map provides a solid basis for exploring epigenetic mechanisms of adipose deposition and muscle growth.

Suggested Citation

  • Mingzhou Li & Honglong Wu & Zonggang Luo & Yudong Xia & Jiuqiang Guan & Tao Wang & Yiren Gu & Lei Chen & Kai Zhang & Jideng Ma & Yingkai Liu & Zhijun Zhong & Jing Nie & Shuling Zhou & Zhiping Mu & Xia, 2012. "An atlas of DNA methylomes in porcine adipose and muscle tissues," Nature Communications, Nature, vol. 3(1), pages 1-11, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms1854
    DOI: 10.1038/ncomms1854
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms1854
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms1854?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Wen-Kui Sun & Chi Cheng & Rui Liu & Yi-Hui Chen & Kai Zeng & Xiao-Hui Chen & Yi-Ren Gu & Jiang-Ling Li & Xue-Bin Lv & Rong Gao, 2019. "Expression patterns of GHRL, GHSR, LEP, LEPR, SST and CCK genes in the gastrointestinal tissues of Tibetan and Yorkshire pigs," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 64(6), pages 239-247.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms1854. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.