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Bats host major mammalian paramyxoviruses

Author

Listed:
  • Jan Felix Drexler

    (Institute of Virology, University of Bonn Medical Centre)

  • Victor Max Corman

    (Institute of Virology, University of Bonn Medical Centre)

  • Marcel Alexander Müller

    (Institute of Virology, University of Bonn Medical Centre)

  • Gael Darren Maganga

    (Centre International de Recherches Médicales de Franceville)

  • Peter Vallo

    (Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic, v.v.i.)

  • Tabea Binger

    (Institute of Virology, University of Bonn Medical Centre)

  • Florian Gloza-Rausch

    (Institute of Virology, University of Bonn Medical Centre
    Noctalis, Centre for Bat Protection and Information)

  • Veronika M. Cottontail

    (Institute of Experimental Ecology, University of Ulm)

  • Andrea Rasche

    (Institute of Virology, University of Veterinary Medicine Hannover Foundation)

  • Stoian Yordanov

    (Forestry Board Directorate of Strandja Natural Park)

  • Antje Seebens

    (Noctalis, Centre for Bat Protection and Information)

  • Mirjam Knörnschild

    (Institute of Experimental Ecology, University of Ulm)

  • Samuel Oppong

    (Kwame Nkrumah University of Science and Technology)

  • Yaw Adu Sarkodie

    (Kwame Nkrumah University of Science and Technology)

  • Célestin Pongombo

    (University of Lubumbashi)

  • Alexander N. Lukashev

    (Chumakov Institute of Poliomyelitis and Viral Encephalitides)

  • Jonas Schmidt-Chanasit

    (Bernhard Nocht Institute for Tropical Medicine)

  • Andreas Stöcker

    (Infectious Diseases Research Laboratory, University Hospital Professor Edgard Santos, Federal University of Bahia)

  • Aroldo José Borges Carneiro

    (School of Veterinary Medicine, Federal University of Bahia)

  • Stephanie Erbar

    (Institute of Virology, Philipps University of Marburg)

  • Andrea Maisner

    (Institute of Virology, Philipps University of Marburg)

  • Florian Fronhoffs

    (Institute of Pathology, University of Bonn Medical Centre)

  • Reinhard Buettner

    (Institute of Pathology, University of Bonn Medical Centre
    Institute of Pathology, University of Cologne Medical Centre)

  • Elisabeth K. V. Kalko

    (Institute of Experimental Ecology, University of Ulm
    Smithsonian Tropical Research Institute)

  • Thomas Kruppa

    (Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR))

  • Carlos Roberto Franke

    (School of Veterinary Medicine, Federal University of Bahia)

  • René Kallies

    (Institute of Virology, University of Bonn Medical Centre)

  • Emmanuel R.N. Yandoko

    (Pasteur Institute)

  • Georg Herrler

    (Institute of Virology, University of Veterinary Medicine Hannover Foundation)

  • Chantal Reusken

    (Netherlands Center for Infectious Disease Control)

  • Alexandre Hassanin

    (Muséum National d'Histoire Naturelle/Centre National de la Recherche Scientifique, UMR 7205)

  • Detlev H. Krüger

    (Institute of Medical Virology (Helmut Ruska Haus), Charité Medical School)

  • Sonja Matthee

    (Stellenbosch University)

  • Rainer G. Ulrich

    (Institute for Novel and Emerging Infections Diseases, Friedrich-Loeffler-Institut, Institute for Novel and Emerging Infectious Diseases)

  • Eric M. Leroy

    (Centre International de Recherches Médicales de Franceville
    Institut de Recherche pour le Développement, UMR 224 (MIVEGEC), IRD/CNRS/UM1)

  • Christian Drosten

    (Institute of Virology, University of Bonn Medical Centre)

Abstract

The large virus family Paramyxoviridae includes some of the most significant human and livestock viruses, such as measles-, distemper-, mumps-, parainfluenza-, Newcastle disease-, respiratory syncytial virus and metapneumoviruses. Here we identify an estimated 66 new paramyxoviruses in a worldwide sample of 119 bat and rodent species (9,278 individuals). Major discoveries include evidence of an origin of Hendra- and Nipah virus in Africa, identification of a bat virus conspecific with the human mumps virus, detection of close relatives of respiratory syncytial virus, mouse pneumonia- and canine distemper virus in bats, as well as direct evidence of Sendai virus in rodents. Phylogenetic reconstruction of host associations suggests a predominance of host switches from bats to other mammals and birds. Hypothesis tests in a maximum likelihood framework permit the phylogenetic placement of bats as tentative hosts at ancestral nodes to both the major Paramyxoviridae subfamilies (Paramyxovirinae and Pneumovirinae). Future attempts to predict the emergence of novel paramyxoviruses in humans and livestock will have to rely fundamentally on these data.

Suggested Citation

  • Jan Felix Drexler & Victor Max Corman & Marcel Alexander Müller & Gael Darren Maganga & Peter Vallo & Tabea Binger & Florian Gloza-Rausch & Veronika M. Cottontail & Andrea Rasche & Stoian Yordanov & A, 2012. "Bats host major mammalian paramyxoviruses," Nature Communications, Nature, vol. 3(1), pages 1-13, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms1796
    DOI: 10.1038/ncomms1796
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    Cited by:

    1. Yingying Guo & Songyue Wu & Wenting Li & Haonan Yang & Tianhao Shi & Bin Ju & Zheng Zhang & Renhong Yan, 2024. "The cryo-EM structure of homotetrameric attachment glycoprotein from langya henipavirus," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Johannes P. M. Langedijk & Freek Cox & Nicole V. Johnson & Daan Overveld & Lam Le & Ward Hoogen & Richard Voorzaat & Roland Zahn & Leslie Fits & Jarek Juraszek & Jason S. McLellan & Mark J. G. Bakkers, 2024. "Universal paramyxovirus vaccine design by stabilizing regions involved in structural transformation of the fusion protein," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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