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Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS

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  • Zhu A. Wang

    (Columbia University
    Present address: Department of Genetics & Development, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York 10032, USA.)

  • Jianhua Huang

    (Columbia University)

  • Daniel Kalderon

    (Columbia University)

Abstract

The mechanisms underlying adult stem cell behaviour are likely to be diverse and have not yet been investigated systematically. Here we conducted an unbiased genetic screen using Drosophila ovarian follicle stem cells to probe essential functions regulating self-renewal of epithelial stem cells. Surprisingly, we find that niche adhesion emerges as the most commonly affected essential stem cell property, and that proliferation is critical for stem cell maintenance. We also find that PI3K pathway activation enhances follicle stem cell function, whereas mitochondrial dysfunction and reactive oxygen species production lead to stem cell loss. Moreover, we find that most genes required specifically in the stem cell of the follicle stem cell lineage are widely expressed but are not required for the maintenance of ovarian germline stem cells. These findings highlight the fundamental characteristics of follicle stem cells as an important stem cell paradigm that contrasts with some other stem cell models, where repression of differentiation or relative quiescence is crucial.

Suggested Citation

  • Zhu A. Wang & Jianhua Huang & Daniel Kalderon, 2012. "Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS," Nature Communications, Nature, vol. 3(1), pages 1-10, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms1765
    DOI: 10.1038/ncomms1765
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    Cited by:

    1. Lan Pang & Zhiguo Liu & Jiani Chen & Zhi Dong & Sicong Zhou & Qichao Zhang & Yueqi Lu & Yifeng Sheng & Xuexin Chen & Jianhua Huang, 2022. "Search performance and octopamine neuronal signaling mediate parasitoid induced changes in Drosophila oviposition behavior," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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