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Network physiology reveals relations between network topology and physiological function

Author

Listed:
  • Amir Bashan

    (Bar-Ilan University)

  • Ronny P. Bartsch

    (Brigham and Women's Hospital)

  • Jan. W. Kantelhardt

    (Institute of Physics, Martin-Luther-Universität Halle-Wittenberg)

  • Shlomo Havlin

    (Bar-Ilan University)

  • Plamen Ch. Ivanov

    (Brigham and Women's Hospital
    Boston University
    Institute of Solid State Physics, Bulgarian Academy of Sciences)

Abstract

The human organism is an integrated network where complex physiological systems, each with its own regulatory mechanisms, continuously interact, and where failure of one system can trigger a breakdown of the entire network. Identifying and quantifying dynamical networks of diverse systems with different types of interactions is a challenge. Here we develop a framework to probe interactions among diverse systems, and we identify a physiological network. We find that each physiological state is characterized by a specific network structure, demonstrating a robust interplay between network topology and function. Across physiological states, the network undergoes topological transitions associated with fast reorganization of physiological interactions on time scales of a few minutes, indicating high network flexibility in response to perturbations. The proposed system-wide integrative approach may facilitate the development of a new field, Network Physiology.

Suggested Citation

  • Amir Bashan & Ronny P. Bartsch & Jan. W. Kantelhardt & Shlomo Havlin & Plamen Ch. Ivanov, 2012. "Network physiology reveals relations between network topology and physiological function," Nature Communications, Nature, vol. 3(1), pages 1-9, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms1705
    DOI: 10.1038/ncomms1705
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