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Existence of long-lasting experience-dependent plasticity in endocrine cell networks

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  • David J. Hodson

    (CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier F-34000, France.
    INSERM, U661, Montpellier F-34000, France.
    UMR-5203, Universités de Montpellier 1 & 2, Montpellier F-34000, France.)

  • Marie Schaeffer

    (CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier F-34000, France.
    INSERM, U661, Montpellier F-34000, France.
    UMR-5203, Universités de Montpellier 1 & 2, Montpellier F-34000, France.
    Royal College of Surgeons in Ireland, Dublin 17, Ireland.)

  • Nicola Romanò

    (CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier F-34000, France.
    INSERM, U661, Montpellier F-34000, France.
    UMR-5203, Universités de Montpellier 1 & 2, Montpellier F-34000, France.)

  • Pierre Fontanaud

    (CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier F-34000, France.
    INSERM, U661, Montpellier F-34000, France.
    UMR-5203, Universités de Montpellier 1 & 2, Montpellier F-34000, France.)

  • Chrystel Lafont

    (CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier F-34000, France.
    INSERM, U661, Montpellier F-34000, France.
    UMR-5203, Universités de Montpellier 1 & 2, Montpellier F-34000, France.)

  • Jerome Birkenstock

    (CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier F-34000, France.
    INSERM, U661, Montpellier F-34000, France.
    UMR-5203, Universités de Montpellier 1 & 2, Montpellier F-34000, France.)

  • François Molino

    (CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier F-34000, France.
    INSERM, U661, Montpellier F-34000, France.
    UMR-5203, Universités de Montpellier 1 & 2, Montpellier F-34000, France.)

  • Helen Christian

    (Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.)

  • Joe Lockey

    (Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.)

  • Danielle Carmignac

    (MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.)

  • Marta Fernandez-Fuente

    (MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.)

  • Paul Le Tissier

    (MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.)

  • Patrice Mollard

    (CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier F-34000, France.
    INSERM, U661, Montpellier F-34000, France.
    UMR-5203, Universités de Montpellier 1 & 2, Montpellier F-34000, France.)

Abstract

Experience-dependent plasticity of cell and tissue function is critical for survival by allowing organisms to dynamically adjust physiological processes in response to changing or harsh environmental conditions. Despite the conferred evolutionary advantage, it remains unknown whether emergent experience-dependent properties are present in cell populations organized as networks within endocrine tissues involved in regulating body-wide homeostasis. Here we show, using lactation to repeatedly activate a specific endocrine cell network in situ in the mammalian pituitary, that templates of prior demand are permanently stored through stimulus-evoked alterations to the extent and strength of cell–cell connectivity. Strikingly, following repeat stimulation, evolved population behaviour leads to improved tissue output. As such, long-lasting experience-dependent plasticity is an important feature of endocrine cell networks and underlies functional adaptation of hormone release.

Suggested Citation

  • David J. Hodson & Marie Schaeffer & Nicola Romanò & Pierre Fontanaud & Chrystel Lafont & Jerome Birkenstock & François Molino & Helen Christian & Joe Lockey & Danielle Carmignac & Marta Fernandez-Fuen, 2012. "Existence of long-lasting experience-dependent plasticity in endocrine cell networks," Nature Communications, Nature, vol. 3(1), pages 1-10, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms1612
    DOI: 10.1038/ncomms1612
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    Cited by:

    1. Thomas H Hraha & Matthew J Westacott & Marina Pozzoli & Aleena M Notary & P Mason McClatchey & Richard K P Benninger, 2014. "Phase Transitions in the Multi-cellular Regulatory Behavior of Pancreatic Islet Excitability," PLOS Computational Biology, Public Library of Science, vol. 10(9), pages 1-14, September.

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