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Modulation of rod photoreceptor output by HCN1 channels is essential for regular mesopic cone vision

Author

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  • Mathias W. Seeliger

    (Institute for Ophthalmic Research, Centre for Ophthalmology, Eberhard Karls University of Tübingen, Schleichstr. 4/3, D-72076 Tübingen, Germany.)

  • Arne Brombas

    (Institute of Complex Systems, Cellular Biophysics (ICS-4), Forschungszentrum Jülich
    Present address: Queensland Brain Institute, The University of Queensland, Upland Road, St Lucia, Queensland 4072, Australia.)

  • Reto Weiler

    (Carl von Ossietzky University)

  • Peter Humphries

    (Ocular Genetics Unit, Trinity College)

  • Gabriel Knop

    (Institute of Complex Systems, Cellular Biophysics (ICS-4), Forschungszentrum Jülich
    Present address: University of Erlangen-Nuremberg, Department of Biology, Animal Physiology, 91058 Erlangen, Germany.)

  • Naoyuki Tanimoto

    (Institute for Ophthalmic Research, Centre for Ophthalmology, Eberhard Karls University of Tübingen, Schleichstr. 4/3, D-72076 Tübingen, Germany.)

  • Frank Müller

    (Institute of Complex Systems, Cellular Biophysics (ICS-4), Forschungszentrum Jülich)

Abstract

Retinal photoreceptors permit visual perception over a wide range of lighting conditions. Rods work best in dim, and cones in bright environments, with considerable functional overlap at intermediate (mesopic) light levels. At many sites in the outer and inner retina where rod and cone signals interact, gap junctions, particularly those containing Connexin36, have been identified. However, little is known about the dynamic processes associated with the convergence of rod and cone system signals into ON- and OFF-pathways. Here we show that proper cone vision under mesopic conditions requires rapid adaptational feedback modulation of rod output via hyperpolarization-activated and cyclic nucleotide-gated channels 1. When these channels are absent, sustained rod responses following bright light exposure saturate the retinal network, resulting in a loss of downstream cone signalling. By specific genetic and pharmacological ablation of key signal processing components, regular cone signalling can be restored, thereby identifying the sites involved in functional rod–cone interactions.

Suggested Citation

  • Mathias W. Seeliger & Arne Brombas & Reto Weiler & Peter Humphries & Gabriel Knop & Naoyuki Tanimoto & Frank Müller, 2011. "Modulation of rod photoreceptor output by HCN1 channels is essential for regular mesopic cone vision," Nature Communications, Nature, vol. 2(1), pages 1-10, September.
    • Handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1540
    DOI: 10.1038/ncomms1540
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    Cited by:

    1. Marcus H C Howlett & Robert G Smith & Maarten Kamermans, 2017. "A novel mechanism of cone photoreceptor adaptation," PLOS Biology, Public Library of Science, vol. 15(4), pages 1-28, April.
    2. Yee-Ling Wong & Pirro Hysi & Gemmy Cheung & Milly Tedja & Quan V Hoang & Stuart W J Tompson & Kristina N Whisenhunt & Virginie Verhoeven & Wanting Zhao & Moritz Hess & Chee-Wai Wong & Annette Kifley &, 2019. "Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium," PLOS ONE, Public Library of Science, vol. 14(8), pages 1-16, August.

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