Author
Listed:
- Vanesa Muncan
(Tytgat Institute for Liver and Intestinal Research, Academic Medical Center
Academic Medical Center
Leiden University Medical Center)
- Jarom Heijmans
(Tytgat Institute for Liver and Intestinal Research, Academic Medical Center
Academic Medical Center
Leiden University Medical Center)
- Stephen D. Krasinski
(Children's Hospital Boston)
- Nikè V. Büller
(Tytgat Institute for Liver and Intestinal Research, Academic Medical Center
Academic Medical Center
Leiden University Medical Center)
- Manon E. Wildenberg
(Tytgat Institute for Liver and Intestinal Research, Academic Medical Center
Academic Medical Center
Leiden University Medical Center)
- Sander Meisner
(Tytgat Institute for Liver and Intestinal Research, Academic Medical Center)
- Marijana Radonjic
(Nutrigenomic Consortium, Top Institute Food and Nutrition)
- Kelly A. Stapleton
(Children's Hospital Boston)
- Wout H. Lamers
(Tytgat Institute for Liver and Intestinal Research, Academic Medical Center)
- Izak Biemond
(Leiden University Medical Center)
- Marius A. van den Bergh Weerman
(Academic Medical Center)
- Dónal O'Carroll
(EMBL Monterotondo Mouse Biology Unit)
- James C. Hardwick
(Leiden University Medical Center)
- Daniel W. Hommes
(Leiden University Medical Center)
- Gijs R. van den Brink
(Tytgat Institute for Liver and Intestinal Research, Academic Medical Center
Academic Medical Center
Leiden University Medical Center)
Abstract
In many mammalian species, the intestinal epithelium undergoes major changes that allow a dietary transition from mother's milk to the adult diet at the end of the suckling period. These complex developmental changes are the result of a genetic programme intrinsic to the gut tube, but its regulators have not been identified. Here we show that transcriptional repressor B lymphocyte-induced maturation protein 1 (Blimp1) is highly expressed in the developing and postnatal intestinal epithelium until the suckling to weaning transition. Intestine-specific deletion of Blimp1 results in growth retardation and excessive neonatal mortality. Mutant mice lack all of the typical epithelial features of the suckling period and are born with features of an adult-like intestine. We conclude that the suckling to weaning transition is regulated by a single transcriptional repressor that delays epithelial maturation.
Suggested Citation
Vanesa Muncan & Jarom Heijmans & Stephen D. Krasinski & Nikè V. Büller & Manon E. Wildenberg & Sander Meisner & Marijana Radonjic & Kelly A. Stapleton & Wout H. Lamers & Izak Biemond & Marius A. van d, 2011.
"Blimp1 regulates the transition of neonatal to adult intestinal epithelium,"
Nature Communications, Nature, vol. 2(1), pages 1-9, September.
Handle:
RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1463
DOI: 10.1038/ncomms1463
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