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The rice mitochondrial iron transporter is essential for plant growth

Author

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  • Khurram Bashir

    (Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan.)

  • Yasuhiro Ishimaru

    (Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan.
    Present address: Faculty of Science and Graduate School of Science, Tohoku University, 6-3 Aramakiaza-aoba, Aoba-ku, Sendai, Miyagi 980-8578, Japan.)

  • Hugo Shimo

    (Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan.)

  • Seiji Nagasaka

    (Graduate School of Life Sciences, Toyo University, 1-1-1 Izumino Itakura-machi)

  • Masaru Fujimoto

    (Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan.)

  • Hideki Takanashi

    (Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan.)

  • Nobuhiro Tsutsumi

    (Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan.)

  • Gynheung An

    (Biotech and Crop Biotech Institute, Kyung Hee University)

  • Hiromi Nakanishi

    (Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan.)

  • Naoko K. Nishizawa

    (Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan.
    Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University)

Abstract

In plants, iron (Fe) is essential for mitochondrial electron transport, heme, and Fe-Sulphur (Fe-S) cluster synthesis; however, plant mitochondrial Fe transporters have not been identified. Here we show, identify and characterize the rice mitochondrial Fe transporter (MIT). Based on a transfer DNA library screen, we identified a rice line showing symptoms of Fe deficiency while accumulating high shoot levels of Fe. Homozygous knockout of MIT in this line resulted in a lethal phenotype. MIT localized to the mitochondria and complemented the growth of Δmrs3Δmrs4 yeast defective in mitochondrial Fe transport. The growth of MIT-knockdown (mit-2) plants was also significantly impaired despite abundant Fe accumulation. Further, the decrease in the activity of the mitochondrial and cytosolic Fe-S enzyme, aconitase, indicated that Fe-S cluster synthesis is affected in mit-2 plants. These results indicate that MIT is a mitochondrial Fe transporter essential for rice growth and development.

Suggested Citation

  • Khurram Bashir & Yasuhiro Ishimaru & Hugo Shimo & Seiji Nagasaka & Masaru Fujimoto & Hideki Takanashi & Nobuhiro Tsutsumi & Gynheung An & Hiromi Nakanishi & Naoko K. Nishizawa, 2011. "The rice mitochondrial iron transporter is essential for plant growth," Nature Communications, Nature, vol. 2(1), pages 1-7, September.
    • Handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1326
    DOI: 10.1038/ncomms1326
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    Cited by:

    1. Tim L. Jeffers & Samuel O. Purvine & Carrie D. Nicora & Ryan McCombs & Shivani Upadhyaya & Adrien Stroumza & Ken Whang & Sean D. Gallaher & Alice Dohnalkova & Sabeeha S. Merchant & Mary Lipton & Krish, 2024. "Iron rescues glucose-mediated photosynthesis repression during lipid accumulation in the green alga Chromochloris zofingiensis," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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