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The global distribution of the Duffy blood group

Author

Listed:
  • Rosalind E. Howes

    (Spatial Ecology and Epidemiology Group, Tinbergen Building, University of Oxford)

  • Anand P. Patil

    (Spatial Ecology and Epidemiology Group, Tinbergen Building, University of Oxford)

  • Frédéric B. Piel

    (Spatial Ecology and Epidemiology Group, Tinbergen Building, University of Oxford)

  • Oscar A. Nyangiri

    (Kenya Medical Research Institute (KEMRI)/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, PO Box 230, Kilifi District Hospital, Kilifi 80108, Kenya.)

  • Caroline W. Kabaria

    (Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, KEMRI—University of Oxford—Wellcome Trust Collaborative Programme, Kenyatta National Hospital Grounds (behind NASCOP))

  • Peter W. Gething

    (Spatial Ecology and Epidemiology Group, Tinbergen Building, University of Oxford)

  • Peter A. Zimmerman

    (Center for Global Health and Diseases, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, Ohio 44106-7286, USA.)

  • Céline Barnadas

    (Vector Borne Diseases Unit, Papua New Guinea Institute for Medical Research)

  • Cynthia M. Beall

    (Case Western Reserve University, 238 Mather Memorial Building, 11220 Bellflower Road, Cleveland, Ohio 44106-7125, USA.)

  • Amha Gebremedhin

    (Department of Internal Medicine
    Faculty of Medicine, Addis Ababa University)

  • Didier Ménard

    (Molecular Epidemiology Unit, Pasteur Institute of Cambodia)

  • Thomas N. Williams

    (Kenya Medical Research Institute (KEMRI)/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, PO Box 230, Kilifi District Hospital, Kilifi 80108, Kenya.)

  • David J. Weatherall

    (Weatherall Institute of Molecular Medicine, John Radcliffe Hospital)

  • Simon I. Hay

    (Spatial Ecology and Epidemiology Group, Tinbergen Building, University of Oxford)

Abstract

Blood group variants are characteristic of population groups, and can show conspicuous geographic patterns. Interest in the global prevalence of the Duffy blood group variants is multidisciplinary, but of particular importance to malariologists due to the resistance generally conferred by the Duffy-negative phenotype against Plasmodium vivax infection. Here we collate an extensive geo-database of surveys, forming the evidence-base for a multi-locus Bayesian geostatistical model to generate global frequency maps of the common Duffy alleles to refine the global cartography of the common Duffy variants. We show that the most prevalent allele globally was FY*A, while across sub-Saharan Africa the predominant allele was the silent FY*BES variant, commonly reaching fixation across stretches of the continent. The maps presented not only represent the first spatially and genetically comprehensive description of variation at this locus, but also constitute an advance towards understanding the transmission patterns of the neglected P. vivax malaria parasite.

Suggested Citation

  • Rosalind E. Howes & Anand P. Patil & Frédéric B. Piel & Oscar A. Nyangiri & Caroline W. Kabaria & Peter W. Gething & Peter A. Zimmerman & Céline Barnadas & Cynthia M. Beall & Amha Gebremedhin & Didier, 2011. "The global distribution of the Duffy blood group," Nature Communications, Nature, vol. 2(1), pages 1-10, September.
    • Handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1265
    DOI: 10.1038/ncomms1265
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    Cited by:

    1. Cervellati, Matteo & Esposito, Elena & Sunde, Uwe & Yuan, Song, 2022. "Malaria and Chinese economic activities in Africa," Journal of Development Economics, Elsevier, vol. 154(C).

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