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Comparative transcriptome analysis reveals vertebrate phylotypic period during organogenesis

Author

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  • Naoki Irie

    (Laboratory for Evolutionary Morphology, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minami, Chuo-ku, Kobe, Hyogo 650-0047, Japan.)

  • Shigeru Kuratani

    (Laboratory for Evolutionary Morphology, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minami, Chuo-ku, Kobe, Hyogo 650-0047, Japan.)

Abstract

One of the central issues in evolutionary developmental biology is how we can formulate the relationships between evolutionary and developmental processes. Two major models have been proposed: the 'funnel-like' model, in which the earliest embryo shows the most conserved morphological pattern, followed by diversifying later stages, and the 'hourglass' model, in which constraints are imposed to conserve organogenesis stages, which is called the phylotypic period. Here we perform a quantitative comparative transcriptome analysis of several model vertebrate embryos and show that the pharyngula stage is most conserved, whereas earlier and later stages are rather divergent. These results allow us to predict approximate developmental timetables between different species, and indicate that pharyngula embryos have the most conserved gene expression profiles, which may be the source of the basic body plan of vertebrates.

Suggested Citation

  • Naoki Irie & Shigeru Kuratani, 2011. "Comparative transcriptome analysis reveals vertebrate phylotypic period during organogenesis," Nature Communications, Nature, vol. 2(1), pages 1-8, September.
    • Handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1248
    DOI: 10.1038/ncomms1248
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    Cited by:

    1. Marie Sémon & Marion Mouginot & Manon Peltier & Claudine Corneloup & Philippe Veber & Laurent Guéguen & Sophie Pantalacci, 2025. "Comparative transcriptomics in serial organs uncovers early and pan-organ developmental changes associated with organ-specific morphological adaptation," Nature Communications, Nature, vol. 16(1), pages 1-17, December.
    2. Hao Wu & Ruqiang Zhang & Karl J. Niklas & Michael J. Scanlon, 2025. "Multiplexed transcriptomic analyzes of the plant embryonic hourglass," Nature Communications, Nature, vol. 16(1), pages 1-16, December.

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