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Comprehensive catecholaminergic projectome analysis reveals single-neuron integration of zebrafish ascending and descending dopaminergic systems

Author

Listed:
  • Tuan Leng Tay

    (Developmental Biology, Institute Biology I, Faculty of Biology, Albert-Ludwigs-University Freiburg)

  • Olaf Ronneberger

    (Albert-Ludwigs-University Freiburg, Georges-Koehler-Allee Geb 052
    BIOSS—Center for Biological Signaling Studies, University of Freiburg)

  • Soojin Ryu

    (Developmental Biology, Institute Biology I, Faculty of Biology, Albert-Ludwigs-University Freiburg
    Present address: Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg D-69120, Germany.)

  • Roland Nitschke

    (ZBSA Zentrum für Biosystemanalyse, Albert-Ludwigs-University Freiburg
    BIOSS—Center for Biological Signaling Studies, University of Freiburg)

  • Wolfgang Driever

    (Developmental Biology, Institute Biology I, Faculty of Biology, Albert-Ludwigs-University Freiburg
    ZBSA Zentrum für Biosystemanalyse, Albert-Ludwigs-University Freiburg
    Freiburg Institute for Advanced Studies, Albert-Ludwigs-University Freiburg
    BIOSS—Center for Biological Signaling Studies, University of Freiburg)

Abstract

Essential components of animal behaviour are modulated by dopaminergic (DA) and noradrenergic circuitry. In this study, we reveal at cellular resolution the complete set of projections ('projectome') of every single type of DA and noradrenergio neurons in the central nervous system of zebrafish larvae. The most extensive DA projections are established by posterior tubercular otp-dependent neurons, with individual somata integrating the ascending DA system, the descending diencephalospinal, as well as the endohypothalamic circuitry. These findings suggest a major role in the modulation of physiology and behaviour for otp-dependent DA neurons, which correlate with the mammalian A11 group. We further identified an endogenous subpallial DA system that not only provides most of the local DA projections, but also connects to the ventral diencephalon. The catecholaminergic projectome map provides a framework to understand the evolution and function of these neuromodulatory systems.

Suggested Citation

  • Tuan Leng Tay & Olaf Ronneberger & Soojin Ryu & Roland Nitschke & Wolfgang Driever, 2011. "Comprehensive catecholaminergic projectome analysis reveals single-neuron integration of zebrafish ascending and descending dopaminergic systems," Nature Communications, Nature, vol. 2(1), pages 1-12, September.
    • Handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1171
    DOI: 10.1038/ncomms1171
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    Cited by:

    1. Mir Ahsan Ali & Katharina Lischka & Stephanie J. Preuss & Chintan A. Trivedi & Johann H. Bollmann, 2023. "A synaptic corollary discharge signal suppresses midbrain visual processing during saccade-like locomotion," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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