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Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

Author

Listed:
  • Warren R.J.D. Galloway

    (The University Chemical Laboratory, University of Cambridge)

  • Albert Isidro-Llobet

    (The University Chemical Laboratory, University of Cambridge)

  • David R. Spring

    (The University Chemical Laboratory, University of Cambridge)

Abstract

Biologically active molecules can be identified through the screening of small-molecule libraries, but compound collections typically consist of large numbers of structurally similar compounds. Gallowayet al. review how diversity-oriented synthesis can efficiently generate structurally diverse compound libraries.

Suggested Citation

  • Warren R.J.D. Galloway & Albert Isidro-Llobet & David R. Spring, 2010. "Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules," Nature Communications, Nature, vol. 1(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:1:y:2010:i:1:d:10.1038_ncomms1081
    DOI: 10.1038/ncomms1081
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    Cited by:

    1. Cong Fu & Ling He & Hui Xu & Zongpeng Zhang & Xin Chang & Yanfeng Dang & Xiu-Qin Dong & Chun-Jiang Wang, 2024. "Modular access to chiral bridged piperidine-γ-butyrolactones via catalytic asymmetric allylation/aza-Prins cyclization/lactonization sequences," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Jing Gu & Rui-Kun Peng & Chun-Ling Guo & Meng Zhang & Jie Yang & Xiao Yan & Qian Zhou & Hongwei Li & Na Wang & Jinwei Zhu & Qin Ouyang, 2022. "Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein–protein interaction inhibitor," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Zanjiao Liu & Siqiang Fang & Haoze Li & Chunxiu Xiao & Kai Xiao & Zhishan Su & Tianli Wang, 2024. "Organocatalytic skeletal reorganization for enantioselective synthesis of S-stereogenic sulfinamides," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    4. Liam Hudson & Jeremy W. Mason & Matthias V. Westphal & Matthieu J. R. Richter & Jonathan R. Thielman & Bruce K. Hua & Christopher J. Gerry & Guoqin Xia & Heather L. Osswald & John M. Knapp & Zher Yin , 2023. "Diversity-oriented synthesis encoded by deoxyoligonucleotides," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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