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Motion-based DNA detection using catalytic nanomotors

Author

Listed:
  • Jie Wu

    (University of California San Diego)

  • Shankar Balasubramanian

    (University of California San Diego)

  • Daniel Kagan

    (University of California San Diego)

  • Kalayil Manian Manesh

    (University of California San Diego)

  • Susana Campuzano

    (University of California San Diego)

  • Joseph Wang

    (University of California San Diego)

Abstract

Synthetic nanomotors, which convert chemical energy into autonomous motion, hold considerable promise for diverse applications. In this paper, we show the use of synthetic nanomotors for detecting DNA and bacterial ribosomal RNA in a fast, simple and sensitive manner. The new motion-driven DNA-sensing concept relies on measuring changes in the speed of unmodified catalytic nanomotors induced by the dissolution of silver nanoparticle tags captured in a sandwich DNA hybridization assay. The concentration-dependent distance signals are visualized using optical microscopy, particularly through straight-line traces by magnetically aligned 'racing' nanomotors. This nanomotor biodetection strategy could be extended to monitor a wide range of biomolecular interactions using different motion transduction schemes, thus providing a versatile and powerful tool for detecting biological targets.

Suggested Citation

  • Jie Wu & Shankar Balasubramanian & Daniel Kagan & Kalayil Manian Manesh & Susana Campuzano & Joseph Wang, 2010. "Motion-based DNA detection using catalytic nanomotors," Nature Communications, Nature, vol. 1(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:1:y:2010:i:1:d:10.1038_ncomms1035
    DOI: 10.1038/ncomms1035
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    Cited by:

    1. Chia Hsiang Chen & Vincent Gau & Donna D Zhang & Joseph C Liao & Fei-Yue Wang & Pak Kin Wong, 2010. "Statistical Metamodeling for Revealing Synergistic Antimicrobial Interactions," PLOS ONE, Public Library of Science, vol. 5(11), pages 1-7, November.
    2. Jianhong Wang & Hanglong Wu & Xiaowei Zhu & Robby Zwolsman & Stijn R. J. Hofstraat & Yudong Li & Yingtong Luo & Rick R. M. Joosten & Heiner Friedrich & Shoupeng Cao & Loai K. E. A. Abdelmohsen & Jingx, 2024. "Ultrafast light-activated polymeric nanomotors," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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