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Iridium porphyrin-catalysed asymmetric carbene insertion into primary N-adjacent C–H bonds with TON over 1000000

Author

Listed:
  • Zong-Rui Li

    (Shanghai Institute of Organic Chemistry)

  • Kun Zhan

    (The University of Hong Kong)

  • Yi-Jie Wang

    (Shanghai Institute of Organic Chemistry)

  • Liang-Liang Wu

    (Beijing Normal University)

  • Guo-Lin Lu

    (Shanghai Institute of Organic Chemistry)

  • Hao-Yang Wang

    (Shanghai Institute of Organic Chemistry)

  • Xiao-Long Wan

    (Shanghai Institute of Organic Chemistry)

  • Zhen-Jiang Xu

    (Shanghai Institute of Organic Chemistry)

  • Kam-Hung Low

    (The University of Hong Kong)

  • Chi-Ming Che

    (Shanghai Institute of Organic Chemistry
    The University of Hong Kong)

Abstract

Selective functionalization of ubiquitous C-H bonds in organic molecules provides a straightforward and efficient approach to construct complex molecules with fewer synthetic steps and high atom economy, thus promoting more sustainable and economical chemical synthesis. A formidable challenge in the field is to increase the turnover numbers (TONs) for catalytic C-H functionalization reactions reported in the literature (generally

Suggested Citation

  • Zong-Rui Li & Kun Zhan & Yi-Jie Wang & Liang-Liang Wu & Guo-Lin Lu & Hao-Yang Wang & Xiao-Long Wan & Zhen-Jiang Xu & Kam-Hung Low & Chi-Ming Che, 2025. "Iridium porphyrin-catalysed asymmetric carbene insertion into primary N-adjacent C–H bonds with TON over 1000000," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58316-1
    DOI: 10.1038/s41467-025-58316-1
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