IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-58230-6.html
   My bibliography  Save this article

The role of Npt1 in regulating antifungal protein activity in filamentous fungi

Author

Listed:
  • Yu Wang

    (Fujian Agriculture and Forestry University)

  • Sen Wang

    (Fujian Agriculture and Forestry University)

  • Yuanyuan Chen

    (Fujian Agriculture and Forestry University)

  • Chunlan Xie

    (Fujian Agriculture and Forestry University)

  • Haibo Xu

    (Fujian Agriculture and Forestry University)

  • Yunhua Lin

    (Fujian Agriculture and Forestry University)

  • Ranxun Lin

    (Fujian Agriculture and Forestry University)

  • Wanlin Zeng

    (Fujian Agriculture and Forestry University)

  • Xuan Chen

    (Fujian Agriculture and Forestry University)

  • Xinyi Nie

    (Fujian Agriculture and Forestry University)

  • Shihua Wang

    (Fujian Agriculture and Forestry University)

Abstract

Pathogenic filamentous fungi pose a significant threat to global food security and human health. The limitations of available antifungal agents, including resistance and toxicity, highlight the need for developing innovative antifungal strategies. Antifungal proteins (AFPs) are a class of secreted small proteins that exhibit potent antifungal activity against filamentous fungi, yet the underlying mechanism remains partially understood. In this study, we investigate the molecular and cellular effects of two AFPs, PgAFP and AfAFP, on Aspergillus flavus, a representative filamentous fungus. These AFPs affect various fungal phenotypes and exert an intracellular effect by interacting with Ntp1, a fungi exclusive protein modulating diverse fungal traits. We find that Ntp1 amino acids 417–588 are critical for AFP binding and play a role in regulating growth, development, sporulation, sclerotia formation, toxin synthesis, and pathogenicity. Results generated from this study will help to control pathogenic fungi.

Suggested Citation

  • Yu Wang & Sen Wang & Yuanyuan Chen & Chunlan Xie & Haibo Xu & Yunhua Lin & Ranxun Lin & Wanlin Zeng & Xuan Chen & Xinyi Nie & Shihua Wang, 2025. "The role of Npt1 in regulating antifungal protein activity in filamentous fungi," Nature Communications, Nature, vol. 16(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58230-6
    DOI: 10.1038/s41467-025-58230-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-58230-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-025-58230-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58230-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.