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Dynamics of evoked responses in hippocampal pathways are encoded by the duration of vigilance states

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  • Paul Marchal

    (Forgetting processes and cortical dynamics’ team, Centre de Recherche en Neurosciences de Lyon
    University of California Los Angeles)

  • Paul A. Salin

    (Forgetting processes and cortical dynamics’ team, Centre de Recherche en Neurosciences de Lyon
    Institut National de la Santé et de la Recherche Médicale U1028)

  • Mégane Missaire

    (Forgetting processes and cortical dynamics’ team, Centre de Recherche en Neurosciences de Lyon
    Institut National de la Santé et de la Recherche Médicale U1028)

  • Manon Rampon

    (Forgetting processes and cortical dynamics’ team, Centre de Recherche en Neurosciences de Lyon
    Institut National de la Santé et de la Recherche Médicale U1028)

  • Julien Carponcy

    (Forgetting processes and cortical dynamics’ team, Centre de Recherche en Neurosciences de Lyon
    Institut National de la Santé et de la Recherche Médicale U1028)

  • Régis Parmentier

    (Forgetting processes and cortical dynamics’ team, Centre de Recherche en Neurosciences de Lyon
    Institut National de la Santé et de la Recherche Médicale U1028)

  • Gina Poe

    (University of California Los Angeles)

  • Gaël Malleret

    (Forgetting processes and cortical dynamics’ team, Centre de Recherche en Neurosciences de Lyon
    Institut National de la Santé et de la Recherche Médicale U1028)

  • Jean-Christophe Comte

    (Forgetting processes and cortical dynamics’ team, Centre de Recherche en Neurosciences de Lyon
    Institut National de la Santé et de la Recherche Médicale U1028)

Abstract

Interactions among brain areas are essential to most cognitive functions. Neuronal interactions between these areas depend on the modulation of synaptic strength. However, this modulation remains poorly understood. We recorded evoked responses at four hippocampal pathways in freely moving male rats across 24 hours. We show that synaptic strength at these pathways oscillates with a very slow periodicity and correlates with the durations of vigilance states. A model based on hypnogram data and synaptic strength at one pathway was able to predict the evolution of synaptic strength at most pathways, except one. These results reveal that the temporal succession of vigilance states may contribute to memory processes through rapid modulation of synaptic strength at several pathways during the sleep-wakefulness cycle, suggesting that memory processes are not only dependent on sleep amount but also on sleep architecture.

Suggested Citation

  • Paul Marchal & Paul A. Salin & Mégane Missaire & Manon Rampon & Julien Carponcy & Régis Parmentier & Gina Poe & Gaël Malleret & Jean-Christophe Comte, 2025. "Dynamics of evoked responses in hippocampal pathways are encoded by the duration of vigilance states," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57976-3
    DOI: 10.1038/s41467-025-57976-3
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