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Portable molecular diagnostic platform for rapid point-of-care detection of mpox and other diseases

Author

Listed:
  • Matthew L. Cavuto

    (Imperial College London
    Imperial College London)

  • Kenny Malpartida-Cardenas

    (Imperial College London
    Imperial College London)

  • Ivana Pennisi

    (Imperial College London
    Imperial College London)

  • Marcus J. Pond

    (Imperial College Healthcare NHS Trust)

  • Sohail Mirza

    (Imperial College London
    Imperial College London)

  • Nicolas Moser

    (Imperial College London
    Imperial College London)

  • Mark Comer

    (Imperial College London)

  • Isobel Stokes

    (University of Surrey)

  • Lucy Eke

    (University of Surrey)

  • Sian Lant

    (University of Surrey)

  • Katarzyna M. Szostak-Lipowicz

    (Imperial College London)

  • Luca Miglietta

    (Imperial College London)

  • Oliver W. Stringer

    (Imperial College London
    Imperial College London)

  • Katerina-Theresa Mantikas

    (Imperial College London
    Imperial College London)

  • Rebecca P. Sumner

    (University of Surrey)

  • Frances Bolt

    (Imperial College London
    Imperial College London)

  • Shiranee Sriskandan

    (Imperial College London
    Imperial College London)

  • Alison Holmes

    (Imperial College London
    University of Liverpool
    Imperial College London and Imperial College Healthcare NHS Trust)

  • Pantelis Georgiou

    (Imperial College London
    Imperial College London)

  • David O. Ulaeto

    (Defence Science and Technology Laboratory)

  • Carlos Maluquer de Motes

    (University of Surrey)

  • Jesus Rodriguez-Manzano

    (Imperial College London
    Imperial College London)

Abstract

The World Health Organization’s designation of mpox as a public health emergency of international concern in August 2024 underscores the urgent need for effective diagnostic solutions to combat this escalating threat. The rapid global spread of clade II mpox, coupled with the sustained human-to-human transmission of the more virulent clade I mpox in the Democratic Republic of Congo, highlights a critical gap in point-of-care diagnostics for this emergent disease. In response, we developed Dragonfly, a portable molecular diagnostic platform for point-of-care use that integrates power-free nucleic acid extraction (

Suggested Citation

  • Matthew L. Cavuto & Kenny Malpartida-Cardenas & Ivana Pennisi & Marcus J. Pond & Sohail Mirza & Nicolas Moser & Mark Comer & Isobel Stokes & Lucy Eke & Sian Lant & Katarzyna M. Szostak-Lipowicz & Luca, 2025. "Portable molecular diagnostic platform for rapid point-of-care detection of mpox and other diseases," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57647-3
    DOI: 10.1038/s41467-025-57647-3
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