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Genomically defined hypervirulent Klebsiella pneumoniae contributed to early-onset increased mortality

Author

Listed:
  • Yunfei Tang

    (Peking University Third Hospital)

  • Pengcheng Du

    (Capital Medical University)

  • Chunjing Du

    (Peking University Third Hospital)

  • Ping Yang

    (Peking University Third Hospital)

  • Ning Shen

    (Peking University Third Hospital)

  • Thomas A. Russo

    (Buffalo
    Buffalo)

  • Chao Liu

    (Peking University Third Hospital)

Abstract

The presence of all five of the virulence-associated genes iucA, iroB, peg-344, rmpA, and rmpA2 is presently the most accurate genomic means for predicting hypervirulent Klebsiella pneumoniae (hvKp-p). With this longitudinal cohort study, we firstly provide novel insights into the clinical and genomic characteristics of hvKp-p in high-risk regions. Through propensity score matching, we show that hvKp-p is less likely to acquire antimicrobial resistance but develops more severe disease and result in increased mortality. HvKp-p are predominantly isolated from hospital settings and caused pneumonia in majority of the cases. ST23 and KL1 are the most common types in the hvKp-p cohort. Community-acquired and healthcare-associated infections are also identified as independent risk factors for hvKp-p. This genomic definition, albeit imperfect, offers a practical and efficient alternative to murine models, allowing for early identification and timely intervention in clinical settings.

Suggested Citation

  • Yunfei Tang & Pengcheng Du & Chunjing Du & Ping Yang & Ning Shen & Thomas A. Russo & Chao Liu, 2025. "Genomically defined hypervirulent Klebsiella pneumoniae contributed to early-onset increased mortality," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57379-4
    DOI: 10.1038/s41467-025-57379-4
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    References listed on IDEAS

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    1. Ruobing Wang & Anru Zhang & Shijun Sun & Guankun Yin & Xingyu Wu & Qi Ding & Qi Wang & Fengning Chen & Shuyi Wang & Lucy Dorp & Yawei Zhang & Longyang Jin & Xiaojuan Wang & Francois Balloux & Hui Wang, 2024. "Increase in antioxidant capacity associated with the successful subclone of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11-KL64," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
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