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Fabrication of atomically dispersed barium hydride catalysts for the synthesis of deuterated alkylarenes

Author

Listed:
  • Yongli Cai

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Li Rao

    (Central China Normal University)

  • Yun Wang

    (Dalian Polytechnic University)

  • Fei Chang

    (Yongjiang Laboratory)

  • Teng He

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Yang Zhao

    (Chinese Academy of Sciences)

  • Jiafeng Yu

    (Chinese Academy of Sciences)

  • Hong Wen

    (Chinese Academy of Sciences)

  • Jingai Hao

    (Dalian Polytechnic University)

  • Anan Wu

    (Xiamen University)

  • Bing-Tao Guan

    (Fudan University)

  • Jianping Guo

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Ping Chen

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

Abstract

Marvelous natures of alkali and alkaline earth metal hydrides in catalyzing chemical transformations are being discovered. However, the synthesis of (sub)nanostructured metal hydrides, critically important to enhance their catalytic performances, is yet a very challenging task. Herein, we develop a highly reactive heterogeneous catalyst comprising atomically dispersed barium hydrides on MgO support with an ultrahigh barium loading of up to 20 wt% via a convenient preparation method involving liquid-ammonia impregnation followed by hydrogenation. The surface barium hydride species not only exhibits extraordinary reactivity toward H2 activation at room temperature, but also enables the highly efficient hydrogen isotope exchange (HIE) of both sp3 C–H and sp2 C–H bonds in nonactivated alkylarenes using D2 as the deuterium source under mild conditions. The deuteration rate at benzylic site is two orders of magnitude higher than that of bulk BaH2. This study offers an alternative synthetic route for the manufacture of deuterium-labeled compounds using a heterogenous transition metal-free hydride catalyst beyond the widely studied molecular metal complexe catalysts.

Suggested Citation

  • Yongli Cai & Li Rao & Yun Wang & Fei Chang & Teng He & Yang Zhao & Jiafeng Yu & Hong Wen & Jingai Hao & Anan Wu & Bing-Tao Guan & Jianping Guo & Ping Chen, 2025. "Fabrication of atomically dispersed barium hydride catalysts for the synthesis of deuterated alkylarenes," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57207-9
    DOI: 10.1038/s41467-025-57207-9
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    References listed on IDEAS

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    1. Renyuan Pony Yu & David Hesk & Nelo Rivera & István Pelczer & Paul J. Chirik, 2016. "Iron-catalysed tritiation of pharmaceuticals," Nature, Nature, vol. 529(7585), pages 195-199, January.
    2. Katsuro Hayashi & Peter V. Sushko & Yasuhiro Hashimoto & Alexander L. Shluger & Hideo Hosono, 2014. "Hydride ions in oxide hosts hidden by hydroxide ions," Nature Communications, Nature, vol. 5(1), pages 1-8, May.
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