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Implantable photoelectrochemical-therapeutic methotrexate monitoring system with dual-atomic docking strategy

Author

Listed:
  • Xiankui Xu

    (East China Normal University)

  • Dawei Xu

    (East China Normal University)

  • Xue Zhou

    (East China Normal University)

  • Jing Huang

    (East China Normal University)

  • Shiting Gu

    (East China Normal University)

  • Zhonghai Zhang

    (East China Normal University)

Abstract

The need for precise modulation of blood concentrations of pharmaceutical molecule, especially for high-risk drugs like Methotrexate (MTX), is underscored by the significant impact of individual variations on treatment efficacy. Achieving selective recognition of pharmaceutical molecules within the complex biological environment is a substantial challenge. To tackle this, we propose a synergistic atomic-molecular docking strategy that utilizes a hybrid-dual single-atom Fe1-Zn1 on a TiO2 photoelectrode to selectively bind to the carboxyl and aminopyrimidine groups of MTX respectively. By integrating this Fe1-Zn1-TiO2 photoelectrode with a microcomputer system, an implantable photoelectrochemical-therapeutic drug monitoring (PEC-TDM) system is developed for real-time, continuous in vivo MTX monitoring. This system facilitates personalized therapeutic decision-making and intelligent drug delivery for individualized cancer therapy, potentially revolutionizing oncological care and enhancing patient outcomes.

Suggested Citation

  • Xiankui Xu & Dawei Xu & Xue Zhou & Jing Huang & Shiting Gu & Zhonghai Zhang, 2025. "Implantable photoelectrochemical-therapeutic methotrexate monitoring system with dual-atomic docking strategy," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57084-2
    DOI: 10.1038/s41467-025-57084-2
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    References listed on IDEAS

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    1. Qiulong Wei & Xiaoqing Chang & Danielle Butts & Ryan DeBlock & Kun Lan & Junbin Li & Dongliang Chao & Dong-Liang Peng & Bruce Dunn, 2023. "Surface-redox sodium-ion storage in anatase titanium oxide," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    2. Naama Kanarek & Heather R. Keys & Jason R. Cantor & Caroline A. Lewis & Sze Ham Chan & Tenzin Kunchok & Monther Abu-Remaileh & Elizaveta Freinkman & Lawrence D. Schweitzer & David M. Sabatini, 2018. "Histidine catabolism is a major determinant of methotrexate sensitivity," Nature, Nature, vol. 559(7715), pages 632-636, July.
    3. Xiangdong Long & Zelong Li & Guang Gao & Peng Sun & Jia Wang & Bingsen Zhang & Jun Zhong & Zheng Jiang & Fuwei Li, 2020. "Graphitic phosphorus coordinated single Fe atoms for hydrogenative transformations," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
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