Nature exposure induces analgesic effects by acting on nociception-related neural processing

Nature exposure has numerous health benefits and might reduce self-reported acute pain. Given the multi-faceted and subjective quality of pain and methodological limitations of prior research, it is unclear whether the evidence indicates genuine analgesic effects or results from domain-general effects and subjective reporting biases. This preregistered neuroimaging study investigates how nature modulates nociception-related and domain-general brain responses to acute pain. Healthy participants (N = 49) receiving electrical shocks report lower pain when exposed to virtual nature compared to matched urban or indoor control settings. Multi-voxel signatures of pain-related brain activation patterns demonstrate that this subjective analgesic effect is associated with reductions in nociception-related rather than domain-general cognitive-emotional neural pain processing. Preregistered region-of-interest analyses corroborate these results, highlighting reduced activation of areas connected to somatosensory aspects of pain processing (thalamus, secondary somatosensory cortex, and posterior insula). These findings demonstrate that virtual nature exposure enables genuine analgesic effects through changes in nociceptive and somatosensory processing, advancing our understanding of how nature may be used to complement non-pharmacological pain treatment. That this analgesic effect can be achieved with easy-to-administer virtual nature exposure has important practical implications and opens novel avenues for research on the precise mechanisms by which nature impacts our mind and brain.