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Triglyceride levels and its association with all-cause mortality and cardiovascular outcomes among patients with heart failure

Author

Listed:
  • Qing-Wen Ren

    (The University of Hong Kong Shen Zhen Hospital
    Queen Mary Hospital)

  • Tiew-Hwa Katherine Teng

    (National Heart Centre
    Duke-NUS Medical School
    University of Western Australia)

  • Wouter Ouwerkerk

    (National Heart Centre
    Department of Dermatology)

  • Yi-Kei Tse

    (Queen Mary Hospital)

  • Christopher Tze Wei Tsang

    (Queen Mary Hospital)

  • Mei-Zhen Wu

    (The University of Hong Kong Shen Zhen Hospital
    Queen Mary Hospital)

  • Hung-Fat Tse

    (The University of Hong Kong Shen Zhen Hospital
    Queen Mary Hospital)

  • Adriaan A. Voors

    (Department of Cardiology)

  • Jasper Tromp

    (National Heart Centre
    Duke-NUS Medical School
    Department of Cardiology
    National University of Singapore)

  • Carolyn S. P. Lam

    (National Heart Centre
    Duke-NUS Medical School)

  • Kai-Hang Yiu

    (The University of Hong Kong Shen Zhen Hospital
    Queen Mary Hospital)

Abstract

Remnant cholesterol, identified by triglyceride-rich lipoprotein, is a significant causal risk factor for ischemic heart diseases. The association of triglyceride levels with all-cause and cause-specific outcomes in heart failure (HF) remains unexplored. Using a previously validated territory-wide clinical information registry, all eligible patients diagnosed with HF (N = 127124) from 2000 to 2020 were included. In this population-based cohort (mean age: 71.4 ± 12.2 years, 51.8% male), the association between triglyceride levels and risk of all-cause mortality and cardiovascular disease was a U-shapedḍ curve. High triglyceride levels (≥3.0 mmol/L) were associated with atherosclerotic cardiovascular disease admission or death; conversely, lower triglyceride levels (

Suggested Citation

  • Qing-Wen Ren & Tiew-Hwa Katherine Teng & Wouter Ouwerkerk & Yi-Kei Tse & Christopher Tze Wei Tsang & Mei-Zhen Wu & Hung-Fat Tse & Adriaan A. Voors & Jasper Tromp & Carolyn S. P. Lam & Kai-Hang Yiu, 2025. "Triglyceride levels and its association with all-cause mortality and cardiovascular outcomes among patients with heart failure," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56790-1
    DOI: 10.1038/s41467-025-56790-1
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