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CD248-targeted BBIR-T cell therapy against late-activated fibroblasts in cardiac repair after myocardial infarction

Author

Listed:
  • Haiting Chen

    (No.218 Jixi Road
    No.321 Zhongshan Road)

  • Ke Hu

    (No.218 Jixi Road)

  • Qi Tang

    (No.101 Longmian Road)

  • Junzhuo Wang

    (No.321 Zhongshan Road)

  • Qianyu Gu

    (No.321 Zhongshan Road)

  • Jiayu Chen

    (No.218 Jixi Road)

  • Jiaxin Hu

    (No.158 Wuyang Road)

  • Ningxin Peng

    (No.218 Jixi Road)

  • Meng Guo

    (No.321 Zhongshan Road)

  • Yaohui Jiang

    (No.321 Zhongshan Road)

  • Qingbo Xu

    (No.79 Qingchun Road)

  • Jun Xie

    (No.218 Jixi Road
    No.321 Zhongshan Road)

Abstract

Excessive cardiac fibrosis is a key cause of heart failure and adverse ventricular remodeling after myocardial infarction. The abnormally activated fibroblasts after scar maturation are the chief culprit. Single-cell RNA sequencing of mouse cardiac interstitial cells after myocardial infarction depicts a late-activated fibroblast subpopulation F-Act and initially identifies its characteristic antigen CD248, which is also verified in human hearts. On this basis, we develop a CD248-targeted biotin-binding immune receptor T cell therapy against F-Act to correct cardiac repair disorders. In our study, the precise removal of F-Act after the scar matured effectively inhibits fibrotic expansion in the peri-infarct zone and improves cardiac function. This therapy provides an idea for the treatment of cardiac fibrosis and also promotes the application of engineered T cells to non-tumor diseases.

Suggested Citation

  • Haiting Chen & Ke Hu & Qi Tang & Junzhuo Wang & Qianyu Gu & Jiayu Chen & Jiaxin Hu & Ningxin Peng & Meng Guo & Yaohui Jiang & Qingbo Xu & Jun Xie, 2025. "CD248-targeted BBIR-T cell therapy against late-activated fibroblasts in cardiac repair after myocardial infarction," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56703-2
    DOI: 10.1038/s41467-025-56703-2
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