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Longitudinal evaluation of circulating tumor DNA in patients undergoing neoadjuvant therapy for early breast cancer using a tumor-informed assay

Author

Listed:
  • Mitchell J. Elliott

    (Princess Margaret Cancer Centre and University of Toronto)

  • Philippe Echelard

    (Université de Sherbrooke)

  • Christodoulos Pipinikas

    (NeoGenomics, Babraham Research Campus)

  • Sasha Main

    (University of Toronto)

  • Jesús Fuentes Antrás

    (Hospital Universitario Quirónsalud)

  • Aaron Dou

    (Princess Margaret Cancer Centre and University of Toronto)

  • Zachary Veitch

    (Royal Victoria Regional Health Centre)

  • Eitan Amir

    (Princess Margaret Cancer Centre and University of Toronto)

  • Michelle B. Nadler

    (Princess Margaret Cancer Centre and University of Toronto)

  • Nicholas Meti

    (McGill University)

  • Eshetu Atenafu

    (University Health Network)

  • Elizabeth Shah

    (Princess Margaret Cancer Centre and University of Toronto)

  • Celeste Yu

    (Princess Margaret Cancer Centre and University of Toronto)

  • Nathan Campbell

    (NeoGenomics, Babraham Research Campus)

  • Robert Ventura

    (NeoGenomics, Babraham Research Campus)

  • Lillian L. Siu

    (Princess Margaret Cancer Centre and University of Toronto)

  • Philippe L. Bedard

    (Princess Margaret Cancer Centre and University of Toronto)

  • Hal K. Berman

    (University Health Network)

  • David W. Cescon

    (Princess Margaret Cancer Centre and University of Toronto)

Abstract

Circulating tumor DNA (ctDNA) is an emerging biomarker for the treatment of early breast cancer (EBC). We sought to evaluate a highly sensitive tumor-informed ctDNA assay in a real-world cohort of patients receiving neoadjuvant therapy (NAT) to assess clinical validity and explore prognostic outcomes. ctDNA is detected in 77.2% (88/114) of participants at baseline, with 18/88 (20.5%) having a baseline estimated variant allele frequency (eVAF) of

Suggested Citation

  • Mitchell J. Elliott & Philippe Echelard & Christodoulos Pipinikas & Sasha Main & Jesús Fuentes Antrás & Aaron Dou & Zachary Veitch & Eitan Amir & Michelle B. Nadler & Nicholas Meti & Eshetu Atenafu , 2025. "Longitudinal evaluation of circulating tumor DNA in patients undergoing neoadjuvant therapy for early breast cancer using a tumor-informed assay," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56658-4
    DOI: 10.1038/s41467-025-56658-4
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